BAIT
SOCS1
CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
suppressor of cytokine signaling 1
GO Process (12)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- cytokine-mediated signaling pathway [IBA, ISS, TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of JAK-STAT cascade [IBA, ISS, NAS]
- negative regulation of insulin receptor signaling pathway [IBA, ISS]
- negative regulation of protein kinase activity [TAS]
- negative regulation of tyrosine phosphorylation of Stat3 protein [ISS]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of protein phosphorylation [ISS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
PRKACB
PKA C-beta, PKACB, RP11-82H13.1
protein kinase, cAMP-dependent, catalytic, beta
GO Process (22)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- activation of phospholipase C activity [TAS]
- activation of protein kinase A activity [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- blood coagulation [TAS]
- carbohydrate metabolic process [TAS]
- cellular response to glucagon stimulus [TAS]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gluconeogenesis [TAS]
- glucose metabolic process [TAS]
- innate immune response [TAS]
- intracellular signal transduction [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- protein phosphorylation [IDA]
- regulation of insulin secretion [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
- transmembrane transport [TAS]
- triglyceride catabolic process [TAS]
- water transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRASG13D) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000 PPIs shows that this network is ... [more]
Nat Commun Dec. 24, 2019; 11(1);499 [Pubmed: 31980649]
Throughput
- High Throughput
Curated By
- BioGRID