PRPS1
Gene Ontology Biological Process
- 5-phosphoribose 1-diphosphate biosynthetic process [TAS]
- carbohydrate metabolic process [TAS]
- hypoxanthine biosynthetic process [IMP]
- nervous system development [IMP]
- purine nucleobase metabolic process [IMP]
- purine nucleotide biosynthetic process [IMP]
- pyrimidine nucleotide biosynthetic process [NAS]
- small molecule metabolic process [TAS]
- urate biosynthetic process [IMP]
Gene Ontology Molecular Function
CAV2
Gene Ontology Biological Process
- caveola assembly [IMP]
- endoplasmic reticulum organization [ISS]
- mitochondrion organization [ISS]
- negative regulation of endothelial cell proliferation [ISS]
- positive regulation of dopamine receptor signaling pathway [IMP]
- regulation of mitosis [IEP]
- skeletal muscle fiber development [ISS]
- vesicle docking [IDA]
- vesicle fusion [IDA]
- vesicle organization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISS]
- caveola [IDA]
- cytoplasmic vesicle [IDA]
- extrinsic component of cytoplasmic side of plasma membrane [IDA]
- integral component of plasma membrane [IDA]
- intracellular [IDA]
- membrane [IDA]
- membrane raft [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- protein complex [IDA]
- transport vesicle [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRASG13D) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000 PPIs shows that this network is ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CAV2 PRPS1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID