BAIT

NREP

C5orf13, D4S114, P311, PRO1873, PTZ17, SEZ17
neuronal regeneration related protein
GO Process (0)
GO Function (1)
GO Component (0)

Gene Ontology Molecular Function

Homo sapiens
PREY

RAB7A

PRO2706, RAB7
RAB7A, member RAS oncogene family
Autophagy Project
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Novel RNA-binding protein P311 binds eukaryotic translation initiation factor 3 subunit b (eIF3b) to promote translation of transforming growth factor ?1-3 (TGF-?1-3).

Yue MM, Lv K, Meredith SC, Martindale JL, Gorospe M, Schuger L

P311, a conserved 8-kDa intracellular protein expressed in brain, smooth muscle, regenerating tissues, and malignant glioblastomas, represents the first documented stimulator of TGF-?1-3 translation in vitro and in vivo. Here we initiated efforts to define the mechanism underlying P311 function. PONDR® (Predictor Of Naturally Disordered Regions) analysis suggested and CD confirmed that P311 is an intrinsically disordered protein, therefore requiring ... [more]

J. Biol. Chem. Dec. 05, 2014; 289(49);33971-83 [Pubmed: 25336651]

Throughput

  • Low Throughput

Curated By

  • BioGRID