SLC8A1
Gene Ontology Biological Process
- blood coagulation [TAS]
- calcium ion export [IDA]
- calcium ion homeostasis [ISS]
- calcium ion import [IDA]
- calcium ion transport into cytosol [ISS]
- cardiac muscle cell development [ISS]
- cardiac muscle contraction [TAS]
- cell communication by electrical coupling involved in cardiac conduction [ISS]
- cellular response to caffeine [ISS]
- cellular response to reactive oxygen species [IDA]
- cellular sodium ion homeostasis [IDA]
- cytosolic calcium ion transport [TAS]
- ion transport [TAS]
- membrane depolarization during cardiac muscle cell action potential [TAS]
- muscle contraction [TAS]
- negative regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of the force of heart contraction [IMP]
- regulation of cardiac muscle contraction by calcium ion signaling [TAS]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [ISS, TAS]
- regulation of cell communication by electrical coupling [TAS]
- regulation of heart rate [ISS]
- regulation of the force of heart contraction [IC, ISS]
- relaxation of cardiac muscle [IC, TAS]
- relaxation of smooth muscle [ISS]
- response to muscle stretch [IMP]
- sodium ion export [IDA]
- sodium ion import [IDA]
- transmembrane transport [TAS]
- vascular smooth muscle contraction [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FXYD1
Gene Ontology Biological Process
- chloride transmembrane transport [TAS]
- chloride transport [TAS]
- ion transmembrane transport [TAS]
- muscle contraction [TAS]
- positive regulation of sodium ion export from cell [ISS]
- regulation of cardiac muscle cell membrane potential [ISS]
- regulation of heart contraction [TAS]
- regulation of sodium ion transmembrane transporter activity [ISS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Development of a high-affinity peptide that prevents phospholemman (PLM) inhibition of the sodium/calcium exchanger 1 (NCX1).
NCX1 (Na(+)/Ca(2+) exchanger 1) is an important regulator of intracellular Ca(2+) and a potential therapeutic target for brain ischaemia and for diastolic heart failure with preserved ejection fraction. PLM (phospholemman), a substrate for protein kinases A and C, has been suggested to regulate NCX1 activity. However, although several studies have demonstrated that binding of phosphorylated PLM (pSer(68)-PLM) leads to NCX1 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLC8A1 FXYD1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID