ERG4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
YSP2
Gene Ontology Biological Process
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
The Role of LAM Genes in the Pheromone-Induced Cell Death of S. cerevisiae Yeast.
Lam1-4 proteins perform non-vesicular transport of sterols from the plasma membrane to the endoplasmic reticulum. Disruption of their function leads to an increase in the content of sterols in the plasma membrane. In mammals, homologs of Lam proteins are responsible for the internalization of plasma cholesterol. The biological role of Lam proteins in yeast remains unclear, since the strains lacking ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: cell death (APO:0000312)
Additional Notes
- Figure 6
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ERG4 YSP2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1785 | BioGRID | 2113841 |
Curated By
- BioGRID