BAIT
ALYREF
ALY, ALY/REF, BEF, REF, THOC4
Aly/REF export factor
GO Process (12)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
- RNA splicing [TAS]
- gene expression [TAS]
- mRNA 3'-end processing [TAS]
- mRNA export from nucleus [IMP, TAS]
- mRNA splicing, via spliceosome [IC, TAS]
- osteoblast differentiation [IDA]
- positive regulation of DNA-templated transcription, elongation [IMP]
- regulation of DNA recombination [IMP]
- replication fork processing [IMP]
- termination of RNA polymerase II transcription [TAS]
- transcription from RNA polymerase II promoter [TAS]
- viral mRNA export from host cell nucleus [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LEF1
LEF-1, TCF10, TCF1ALPHA, TCF7L3
lymphoid enhancer-binding factor 1
GO Process (61)
GO Function (19)
GO Component (5)
Gene Ontology Biological Process
- B cell proliferation [IBA]
- BMP signaling pathway [IBA]
- T-helper 1 cell differentiation [ISS]
- Wnt signaling pathway [IDA]
- alpha-beta T cell differentiation [IBA]
- apoptotic process involved in morphogenesis [IBA]
- canonical Wnt signaling pathway [IDA, IMP]
- cell chemotaxis [IDA]
- cellular response to cytokine stimulus [IMP]
- cellular response to interleukin-4 [IDA]
- chorio-allantoic fusion [IBA]
- dentate gyrus development [IBA]
- embryonic limb morphogenesis [IBA]
- epithelial to mesenchymal transition [ISS]
- eye pigmentation [IBA]
- face morphogenesis [IBA]
- forebrain neuroblast division [IBA]
- forebrain neuron differentiation [IBA]
- forebrain radial glial cell differentiation [IBA]
- formation of radial glial scaffolds [IBA]
- histone H3 acetylation [IMP]
- histone H4 acetylation [IMP]
- hypothalamus development [IBA]
- mammary gland development [IBA]
- muscle fiber development [IBA]
- negative regulation of DNA binding [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of apoptotic process in bone marrow [IMP]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of cell-cell adhesion [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of estrogen receptor binding [IDA]
- negative regulation of interleukin-13 production [IDA]
- negative regulation of interleukin-4 production [IDA]
- negative regulation of interleukin-5 production [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- neural crest cell migration [IBA]
- neutrophil differentiation [IMP]
- odontoblast differentiation [IBA]
- osteoblast differentiation [IEP]
- palate development [ISS]
- paraxial mesoderm formation [IBA]
- patterning of blood vessels [IBA]
- positive regulation by host of viral transcription [IDA]
- positive regulation of cell cycle process [IDA]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IDA, IMP]
- positive regulation of cell proliferation [IDA]
- positive regulation of cell proliferation in bone marrow [IMP]
- positive regulation of cell-cell adhesion [IDA]
- positive regulation of epithelial to mesenchymal transition [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of granulocyte differentiation [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of striated muscle tissue development [IBA]
- somitogenesis [IBA]
- sprouting angiogenesis [IBA]
- steroid hormone mediated signaling pathway [IDA]
- trachea gland development [IBA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [IPI]
- DNA binding [ISS]
- DNA binding, bending [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- armadillo repeat domain binding [IPI]
- beta-catenin binding [IDA, IPI, TAS]
- chromatin binding [IBA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- enhancer binding [IDA]
- estrogen receptor activity [IDA]
- estrogen receptor binding [IDA]
- gamma-catenin binding [IPI]
- histone binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- C2H2 zinc finger domain binding [IPI]
- DNA binding [ISS]
- DNA binding, bending [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- armadillo repeat domain binding [IPI]
- beta-catenin binding [IDA, IPI, TAS]
- chromatin binding [IBA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- enhancer binding [IDA]
- estrogen receptor activity [IDA]
- estrogen receptor binding [IDA]
- gamma-catenin binding [IPI]
- histone binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function.
LEF-1 is a transcription factor that participates in the regulation of the T-cell receptor alpha (TCR alpha) enhancer by facilitating the assembly of multiple proteins into a higher order nucleoprotein complex. The function of LEF-1 is dependent, in part, on the HMG domain that induces a sharp bend in the DNA helix, and on an activation domain that stimulates transcription ... [more]
Genes Dev. Mar. 01, 1997; 11(5);640-53 [Pubmed: 9119228]
Throughput
- Low Throughput
Curated By
- BioGRID