BAIT
EMC4
PIG17, TMEM85, HSPC184
ER membrane protein complex subunit 4
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Homo sapiens
PREY
SEC13
D3S1231E, SEC13L1, SEC13R, npp-20
SEC13 homolog (S. cerevisiae)
GO Process (10)
GO Function (1)
GO Component (8)
Gene Ontology Biological Process
- COPII vesicle coating [TAS]
- ER to Golgi vesicle-mediated transport [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- intracellular protein transport [NAS]
- membrane organization [TAS]
- mitotic cell cycle [TAS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.
The flaviviruses dengue virus (DENV) and Zika virus (ZIKV) are severe health threats with rapidly expanding ranges. To identify the host cell dependencies of DENV and ZIKV, we completed orthologous functional genomic screens using RNAi and CRISPR/Cas9 approaches. The screens recovered the ZIKV entry factor AXL as well as multiple host factors involved in endocytosis (RAB5C and RABGEF), heparin sulfation ... [more]
Cell Rep Dec. 28, 2015; 16(1);232-246 [Pubmed: 27342126]
Throughput
- High Throughput
Curated By
- BioGRID