OPRM1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- acute inflammatory response to antigenic stimulus [IEP]
- adenylate cyclase-activating dopamine receptor signaling pathway [ISO]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [IDA, ISO]
- adenylate cyclase-inhibiting opioid receptor signaling pathway [IDA]
- behavioral response to ethanol [ISO]
- calcium ion transmembrane transport [IMP]
- cellular response to morphine [IDA, IMP]
- immune response [TAS]
- locomotory behavior [ISO]
- negative regulation of Wnt protein secretion [ISO, ISS]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of cAMP-mediated signaling [ISO, ISS]
- negative regulation of cytosolic calcium ion concentration [ISO, ISS]
- negative regulation of nitric oxide biosynthetic process [ISO, ISS]
- neuropeptide signaling pathway [IBA, ISO]
- opioid receptor signaling pathway [IDA]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of appetite [IMP]
- positive regulation of cAMP-mediated signaling [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of neurogenesis [ISO, ISS]
- positive regulation of nitric oxide biosynthetic process [ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- regulation of excitatory postsynaptic membrane potential [IDA]
- regulation of sensory perception of pain [IDA]
- response to cocaine [IEP]
- response to ethanol [IDA]
- response to food [IEP]
- response to growth factor [IEP]
- response to lipopolysaccharide [IEP]
- response to morphine [IEP]
- sensory perception of pain [ISO, ISS]
- wound healing [IEP]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [IBA, ISO, ISS]
- G-protein beta-subunit binding [IPI]
- G-protein coupled receptor activity [IDA, IMP]
- beta-endorphin receptor activity [IBA, ISO]
- filamin binding [IMP]
- morphine receptor activity [IDA, IMP]
- neuropeptide binding [IBA]
- opioid receptor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- voltage-gated calcium channel activity [IMP]
- G-protein alpha-subunit binding [IBA, ISO, ISS]
- G-protein beta-subunit binding [IPI]
- G-protein coupled receptor activity [IDA, IMP]
- beta-endorphin receptor activity [IBA, ISO]
- filamin binding [IMP]
- morphine receptor activity [IDA, IMP]
- neuropeptide binding [IBA]
- opioid receptor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- voltage-gated calcium channel activity [IMP]
Gene Ontology Cellular Component
TACR1
Gene Ontology Biological Process
- acute inflammatory response [IEP]
- aggressive behavior [IMP]
- angiotensin-mediated drinking behavior [IMP]
- associative learning [IMP]
- behavioral response to pain [IMP]
- eating behavior [IMP]
- learning or memory [IMP]
- long-term memory [IMP]
- neuropeptide signaling pathway [TAS]
- operant conditioning [IMP]
- positive regulation of action potential [IMP]
- positive regulation of blood pressure [IMP]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of hormone secretion [IMP]
- positive regulation of leukocyte migration [IMP]
- positive regulation of lymphocyte proliferation [IMP]
- positive regulation of ossification [IMP]
- positive regulation of renal sodium excretion [IMP]
- positive regulation of saliva secretion [IMP]
- positive regulation of stress fiber assembly [IMP]
- positive regulation of synaptic transmission, GABAergic [IMP]
- positive regulation of synaptic transmission, cholinergic [IMP]
- positive regulation of uterine smooth muscle contraction [IDA]
- positive regulation of vascular permeability [IMP]
- positive regulation of vasoconstriction [IMP]
- regulation of blood pressure [IMP]
- regulation of smooth muscle cell migration [IMP]
- regulation of smooth muscle cell proliferation [IMP]
- response to auditory stimulus [IDA]
- response to electrical stimulus [IEP]
- response to estradiol [IEP]
- response to ethanol [IMP]
- response to heat [IMP]
- response to hormone [IMP]
- response to morphine [IEP]
- response to nicotine [IMP]
- response to organic cyclic compound [IDA]
- response to ozone [IMP]
- response to pain [ISO]
- response to progesterone [IEP]
- sensory perception of pain [IMP, TAS]
- smooth muscle contraction involved in micturition [IMP]
- sperm ejaculation [IMP]
- tachykinin receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Heterodimerization of substance P and mu-opioid receptors regulates receptor trafficking and resensitization.
The micro-opioid receptor (MOR1) and the substance P receptor (NK1) coexist and functionally interact in nociceptive brain regions; however, a molecular basis for this interaction has not been established. Using coimmunoprecipitation and bioluminescence resonance energy transfer (BRET), we show that MOR1 and NK1 can form heterodimers in HEK 293 cells coexpressing the two receptors. Although NK1-MOR1 heterodimerization did not substantially ... [more]
Throughput
- Low Throughput
Additional Notes
- BRET
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TACR1 OPRM1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID