PRR7
GRIN2B
Gene Ontology Biological Process
- action potential [IMP]
- associative learning [IMP]
- behavioral fear response [ISO]
- behavioral response to pain [ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cation transmembrane transport [ISO]
- cation transport [ISO]
- cellular response to amino acid stimulus [IEP]
- cellular response to dsRNA [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to lipid [IEP]
- cellular response to magnesium starvation [IEP]
- cellular response to manganese ion [IEP]
- cellular response to organic cyclic compound [IEP]
- cerebral cortex development [IEP]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- fear response [ISO]
- hippocampus development [IEP]
- in utero embryonic development [ISO]
- ion transmembrane transport [IDA]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- learning [ISO]
- learning or memory [TAS]
- long-term memory [IEP]
- memory [IDA, ISO]
- multicellular organismal response to stress [IEP]
- positive regulation of cell death [IDA, IMP]
- positive regulation of glutamate secretion [IDA]
- positive regulation of synaptic transmission [IMP]
- receptor clustering [IDA]
- regulation of MAPK cascade [IMP]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of postsynaptic membrane potential [ISO]
- regulation of protein kinase A signaling [ISO]
- regulation of synaptic plasticity [ISO]
- response to amine [IEP]
- response to amphetamine [IEP]
- response to calcium ion [IEP]
- response to carbohydrate [IEP]
- response to cocaine [IEP]
- response to cytokine [IEP]
- response to electrical stimulus [IEP]
- response to ethanol [IEP, ISO]
- response to fungicide [IEP]
- response to growth hormone [IEP]
- response to magnesium ion [IEP]
- response to manganese ion [IEP]
- response to mechanical stimulus [IEP]
- response to methylmercury [IEP]
- response to organic cyclic compound [IEP]
- response to other organism [IEP]
- response to toxic substance [IEP]
- rhythmic process [IDA]
- sensory organ development [ISO]
- startle response [ISO]
- suckling behavior [ISO]
- synaptic transmission [ISO]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function- D2 dopamine receptor binding [IPI]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, ISO]
- beta-catenin binding [IPI]
- calcium channel activity [ISO]
- cation channel activity [ISO]
- cell adhesion molecule binding [IPI]
- drug binding [IPI]
- extracellular-glutamate-gated ion channel activity [IDA]
- glycine binding [ISO]
- interleukin-1 receptor binding [IPI]
- ionotropic glutamate receptor activity [IDA]
- ionotropic glutamate receptor binding [IPI]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- receptor binding [IPI]
- zinc ion binding [IDA]
- D2 dopamine receptor binding [IPI]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, ISO]
- beta-catenin binding [IPI]
- calcium channel activity [ISO]
- cation channel activity [ISO]
- cell adhesion molecule binding [IPI]
- drug binding [IPI]
- extracellular-glutamate-gated ion channel activity [IDA]
- glycine binding [ISO]
- interleukin-1 receptor binding [IPI]
- ionotropic glutamate receptor activity [IDA]
- ionotropic glutamate receptor binding [IPI]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- receptor binding [IPI]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, ISO]
- Z disc [IDA]
- cell surface [ISO]
- dendritic spine [IDA]
- membrane [ISO]
- neuron projection [IDA, ISO]
- neuronal postsynaptic density [ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IDA, ISO]
- synapse [IDA, ISO, TAS]
- synaptic cleft [IDA]
- synaptic vesicle [ISO]
- terminal bouton [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Proteomic analysis revealed a novel synaptic proline-rich membrane protein (PRR7) associated with PSD-95 and NMDA receptor.
Proteomic analyses have revealed a novel synaptic proline-rich membrane protein: PRR7 (proline rich 7), in the postsynaptic density (PSD) fraction of rat forebrain. PRR7 is 269 amino acid residues long, and displays a unique architecture, composed of a very short N-terminal extracellular region, a single membrane spanning domain, and a cytoplasmic domain possessing a proline-rich sequence and a C-terminal type-1 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRR7 GRIN2B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID