NGF
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- activation of phospholipase C activity [TAS]
- apoptotic signaling pathway [TAS]
- cell-cell signaling [IBA]
- extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- negative regulation of apoptotic process [TAS]
- negative regulation of cell cycle [TAS]
- negative regulation of neuron apoptotic process [IBA]
- nerve growth factor processing [TAS]
- neuron projection morphogenesis [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of apoptotic process [TAS]
- positive regulation of axonogenesis [TAS]
- positive regulation of gene expression [IMP]
- regulation of axonogenesis [TAS]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- regulation of neuron differentiation [IBA]
- small GTPase mediated signal transduction [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ITGB1
Gene Ontology Biological Process
- B cell differentiation [IC]
- axon guidance [TAS]
- blood coagulation [TAS]
- calcium-independent cell-matrix adhesion [IGI]
- cell junction assembly [TAS]
- cell migration [TAS]
- cell-cell adhesion mediated by integrin [IEP]
- cell-matrix adhesion [IMP]
- cell-substrate adhesion [IMP]
- cellular defense response [TAS]
- extracellular matrix organization [TAS]
- heterotypic cell-cell adhesion [IMP]
- homophilic cell adhesion via plasma membrane adhesion molecules [TAS]
- integrin-mediated signaling pathway [IMP]
- leukocyte cell-cell adhesion [IDA]
- leukocyte migration [TAS]
- leukocyte tethering or rolling [IMP]
- mesodermal cell differentiation [IEP]
- negative regulation of anoikis [IMP]
- positive regulation of apoptotic process [IGI]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- regulation of collagen catabolic process [IDA]
- regulation of immune response [TAS]
- stress fiber assembly [IMP]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell surface [IDA]
- cytoplasm [IDA]
- extracellular vesicular exosome [IDA]
- filopodium [IDA]
- focal adhesion [IDA]
- integrin alpha1-beta1 complex [IDA]
- integrin alpha10-beta1 complex [IDA]
- integrin alpha11-beta1 complex [IDA]
- integrin alpha2-beta1 complex [IDA]
- integrin alpha3-beta1 complex [IDA]
- integrin alpha8-beta1 complex [TAS]
- integrin complex [NAS]
- invadopodium membrane [IDA]
- membrane [IDA]
- membrane raft [IDA]
- neuromuscular junction [IDA]
- plasma membrane [IDA, NAS, TAS]
- receptor complex [IDA]
- ruffle [TAS]
- ruffle membrane [IDA, NAS]
- sarcolemma [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Integrin alpha9 beta1 is a receptor for nerve growth factor and other neurotrophins.
The integrin alpha9beta1 is a multifunctional receptor that interacts with a variety of ligands including vascular cell adhesion molecule 1, tenascin C and osteopontin. We found that this integrin is a receptor for nerve growth factor (NGF) and two other neurotrophins, brain-derived neurotrophic factor and NT3, using a cell adhesion assay with the alpha9SW480 cell line. Interaction of alpha9beta1 with ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID