CACNA1C
Gene Ontology Biological Process
- axon guidance [TAS]
- calcium ion import [IBA]
- calcium ion transport into cytosol [TAS]
- calcium-mediated signaling using extracellular calcium source [TAS]
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- energy reserve metabolic process [TAS]
- membrane depolarization during action potential [IBA]
- positive regulation of cytosolic calcium ion concentration [IDA]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [TAS]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RYR2
Gene Ontology Biological Process
- Purkinje myocyte to ventricular cardiac muscle cell signaling [ISS]
- calcium ion transport [IDA]
- calcium ion transport into cytosol [IDA]
- calcium-mediated signaling [ISS]
- calcium-mediated signaling using intracellular calcium source [IDA]
- cardiac muscle contraction [IMP]
- cardiac muscle hypertrophy [ISS]
- cell communication by electrical coupling involved in cardiac conduction [IC]
- cellular calcium ion homeostasis [ISS]
- cellular response to caffeine [IDA, ISS]
- cellular response to epinephrine stimulus [TAS]
- cytosolic calcium ion homeostasis [ISS]
- detection of calcium ion [IDA]
- embryonic heart tube morphogenesis [ISS]
- establishment of protein localization to endoplasmic reticulum [IDA]
- ion transmembrane transport [TAS]
- left ventricular cardiac muscle tissue morphogenesis [ISS]
- positive regulation of calcium-transporting ATPase activity [IDA]
- positive regulation of heart rate [ISS]
- positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction [ISS]
- positive regulation of sequestering of calcium ion [IDA]
- positive regulation of the force of heart contraction [IMP]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC, ISS]
- regulation of heart rate [IMP]
- release of sequestered calcium ion into cytosol [IDA, ISS]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IMP, ISS]
- response to caffeine [IDA]
- response to hypoxia [ISS]
- response to muscle stretch [IMP]
- response to redox state [IDA]
- sarcoplasmic reticulum calcium ion transport [TAS]
- transmembrane transport [TAS]
- type B pancreatic cell apoptotic process [IMP]
- ventricular cardiac muscle cell action potential [ISS]
Gene Ontology Molecular Function- calcium channel activity [ISS]
- calcium-induced calcium release activity [IDA]
- calcium-release channel activity [IDA]
- calmodulin binding [IMP, IPI, ISS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- intracellular ligand-gated calcium channel activity [ISS]
- ion channel binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IDA]
- protein kinase A regulatory subunit binding [IDA]
- ryanodine-sensitive calcium-release channel activity [IDA]
- suramin binding [IMP]
- calcium channel activity [ISS]
- calcium-induced calcium release activity [IDA]
- calcium-release channel activity [IDA]
- calmodulin binding [IMP, IPI, ISS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- intracellular ligand-gated calcium channel activity [ISS]
- ion channel binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IDA]
- protein kinase A regulatory subunit binding [IDA]
- ryanodine-sensitive calcium-release channel activity [IDA]
- suramin binding [IMP]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Skeletal and cardiac ryanodine receptors bind to the Ca(2+)-sensor region of dihydropyridine receptor alpha(1C) subunit.
In striated muscles, excitation-contraction coupling is mediated by the functional interplay between dihydropyridine receptor L-type calcium channels (DHPR) and ryanodine receptor calcium-release channel (RyR). Although significantly different molecular mechanisms are involved in skeletal and cardiac muscles, bidirectional cross-talk between the two channels has been described in both tissues. In the present study using surface plasmon resonance spectroscopy, we demonstrate that ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID