BAIT
AIFM1
AIF, CMT2D, CMTX4, COWCK, COXPD6, NADMR, NAMSD, PDCD8, RP3-438D16.2
apoptosis-inducing factor, mitochondrion-associated, 1
GO Process (9)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- DNA catabolic process [TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- apoptotic DNA fragmentation [TAS]
- apoptotic process [IMP]
- chromosome condensation [TAS]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- mitochondrial respiratory chain complex I assembly [IMP]
- neuron differentiation [IDA]
- positive regulation of apoptotic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TRDN
CPVT5, TDN, TRISK, RP11-167I10.1
triadin
GO Process (15)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- cellular calcium ion homeostasis [ISS]
- cytoplasmic microtubule organization [ISS]
- endoplasmic reticulum membrane organization [ISS]
- heart contraction [IMP]
- ion transmembrane transport [TAS]
- muscle contraction [TAS]
- negative regulation of ryanodine-sensitive calcium-release channel activity [TAS]
- positive regulation of cell communication by electrical coupling involved in cardiac conduction [ISS]
- positive regulation of ryanodine-sensitive calcium-release channel activity [ISS, TAS]
- regulation of cardiac muscle cell membrane potential [ISS]
- regulation of cell communication by electrical coupling [TAS]
- regulation of release of sequestered calcium ion into cytosol [TAS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISS]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- calcium channel complex [ISS]
- cytoplasm [IDA]
- endoplasmic reticulum [ISS]
- integral component of membrane [TAS]
- junctional membrane complex [ISS]
- junctional sarcoplasmic reticulum membrane [ISS, TAS]
- plasma membrane [IDA]
- sarcoplasmic reticulum [ISS]
- sarcoplasmic reticulum lumen [TAS]
- sarcoplasmic reticulum membrane [TAS]
- voltage-gated calcium channel complex [ISS]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Cells organize their actions partly through tightly controlled protein-protein interactions-collectively termed the interactome. Here we use crosslinking mass spectrometry (XL-MS) to chart the protein-protein interactions in intact human nuclei. Overall, we identified ∼8,700 crosslinks, of which 2/3 represent links connecting distinct proteins. From these data, we gain insights on interactions involving histone proteins. We observed that core histones on the ... [more]
Mol. Cell Proteomics Dec. 01, 2017; 17(10);2018-2033 [Pubmed: 30021884]
Throughput
- High Throughput
Additional Notes
- interaction identified using XL-MS (cross-linking mass spectrometry): lysates from unfractionated cells were treated with cross-linker and cross-linked proteins were identified by mass-spectrometry; interaction is undirectional; therefore bait and prey/hit have been assigned arbitrarily; interactions with FDRs (false discovery rates) of 1% or less were reported; this interaction was not detected in parallel experiments using TX100-soluble or TX100-insoluble fractions
Curated By
- BioGRID