BAIT
KPNA1
AW494490, IPOA5, NPI1, Rch2, mSRP1
karyopherin (importin) alpha 1
GO Process (1)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
LEF1
LEF-1, TCF10, TCF1ALPHA, TCF7L3
lymphoid enhancer-binding factor 1
GO Process (61)
GO Function (19)
GO Component (5)
Gene Ontology Biological Process
- B cell proliferation [IBA]
- BMP signaling pathway [IBA]
- T-helper 1 cell differentiation [ISS]
- Wnt signaling pathway [IDA]
- alpha-beta T cell differentiation [IBA]
- apoptotic process involved in morphogenesis [IBA]
- canonical Wnt signaling pathway [IDA, IMP]
- cell chemotaxis [IDA]
- cellular response to cytokine stimulus [IMP]
- cellular response to interleukin-4 [IDA]
- chorio-allantoic fusion [IBA]
- dentate gyrus development [IBA]
- embryonic limb morphogenesis [IBA]
- epithelial to mesenchymal transition [ISS]
- eye pigmentation [IBA]
- face morphogenesis [IBA]
- forebrain neuroblast division [IBA]
- forebrain neuron differentiation [IBA]
- forebrain radial glial cell differentiation [IBA]
- formation of radial glial scaffolds [IBA]
- histone H3 acetylation [IMP]
- histone H4 acetylation [IMP]
- hypothalamus development [IBA]
- mammary gland development [IBA]
- muscle fiber development [IBA]
- negative regulation of DNA binding [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of apoptotic process in bone marrow [IMP]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of cell-cell adhesion [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of estrogen receptor binding [IDA]
- negative regulation of interleukin-13 production [IDA]
- negative regulation of interleukin-4 production [IDA]
- negative regulation of interleukin-5 production [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- neural crest cell migration [IBA]
- neutrophil differentiation [IMP]
- odontoblast differentiation [IBA]
- osteoblast differentiation [IEP]
- palate development [ISS]
- paraxial mesoderm formation [IBA]
- patterning of blood vessels [IBA]
- positive regulation by host of viral transcription [IDA]
- positive regulation of cell cycle process [IDA]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IDA, IMP]
- positive regulation of cell proliferation [IDA]
- positive regulation of cell proliferation in bone marrow [IMP]
- positive regulation of cell-cell adhesion [IDA]
- positive regulation of epithelial to mesenchymal transition [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of granulocyte differentiation [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of striated muscle tissue development [IBA]
- somitogenesis [IBA]
- sprouting angiogenesis [IBA]
- steroid hormone mediated signaling pathway [IDA]
- trachea gland development [IBA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [IPI]
- DNA binding [ISS]
- DNA binding, bending [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- armadillo repeat domain binding [IPI]
- beta-catenin binding [IDA, IPI, TAS]
- chromatin binding [IBA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- enhancer binding [IDA]
- estrogen receptor activity [IDA]
- estrogen receptor binding [IDA]
- gamma-catenin binding [IPI]
- histone binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- C2H2 zinc finger domain binding [IPI]
- DNA binding [ISS]
- DNA binding, bending [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- armadillo repeat domain binding [IPI]
- beta-catenin binding [IDA, IPI, TAS]
- chromatin binding [IBA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- enhancer binding [IDA]
- estrogen receptor activity [IDA]
- estrogen receptor binding [IDA]
- gamma-catenin binding [IPI]
- histone binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins.
Proteins are directed to the nucleus by their nuclear localization sequences (NLSs) in a multistep process. The first step, which is to dock the NLS-containing protein to the nuclear pore, is carried out in part by a recently identified NLS receptor named Srp1/importin-alpha. Using the high mobility group (HMG) DNA binding domain of human lymphoid enhancer factor-1 (hLEF-1) as bait ... [more]
J. Biol. Chem. Mar. 29, 1996; 271(13);7654-8 [Pubmed: 8631802]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LEF1 KPNA1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID