BAIT
ANK2
ANK-2, LQT4, brank-2
ankyrin 2, neuronal
GO Process (36)
GO Function (7)
GO Component (11)
Gene Ontology Biological Process
- SA node cell action potential [ISS]
- SA node cell to atrial cardiac muscle cell communication [IMP]
- T-tubule organization [ISS]
- atrial cardiac muscle cell action potential [IMP]
- atrial cardiac muscle cell to AV node cell communication [ISS]
- atrial septum development [IMP]
- axon guidance [TAS]
- cellular calcium ion homeostasis [ISS]
- cellular protein localization [IGI]
- membrane depolarization during SA node cell action potential [TAS]
- positive regulation of calcium ion transmembrane transporter activity [ISS]
- positive regulation of calcium ion transport [ISS]
- positive regulation of cation channel activity [ISS]
- positive regulation of gene expression [IGI]
- positive regulation of potassium ion transmembrane transporter activity [ISS]
- positive regulation of potassium ion transport [ISS]
- protein localization to M-band [ISS]
- protein localization to T-tubule [ISS]
- protein localization to cell surface [ISS]
- protein localization to endoplasmic reticulum [IGI]
- protein localization to organelle [IGI]
- protein localization to plasma membrane [IGI, ISS]
- protein stabilization [ISS]
- regulation of calcium ion transmembrane transporter activity [ISS]
- regulation of calcium ion transport [IGI]
- regulation of cardiac muscle cell contraction [IGI]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by calcium ion signaling [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IGI, ISS]
- regulation of heart rate [IMP]
- regulation of heart rate by cardiac conduction [IMP, ISS]
- regulation of protein stability [IC]
- regulation of release of sequestered calcium ion into cytosol [IGI]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- sarcoplasmic reticulum calcium ion transport [TAS]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RRBP1
ES/130, ES130, RRp, hES, RP11-462D18.3
ribosome binding protein 1
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Cells organize their actions partly through tightly controlled protein-protein interactions-collectively termed the interactome. Here we use crosslinking mass spectrometry (XL-MS) to chart the protein-protein interactions in intact human nuclei. Overall, we identified ∼8,700 crosslinks, of which 2/3 represent links connecting distinct proteins. From these data, we gain insights on interactions involving histone proteins. We observed that core histones on the ... [more]
Mol. Cell Proteomics Dec. 01, 2017; 17(10);2018-2033 [Pubmed: 30021884]
Throughput
- High Throughput
Additional Notes
- interaction identified using XL-MS (cross-linking mass spectrometry): TX100-soluble fractions from cells were treated with cross-linker and cross-linked proteins were identified by mass-spectrometry; interaction is undirectional; therefore bait and prey/hit have been assigned arbitrarily; interactions with FDRs (false discovery rates) of 1% or less were reported; this interaction was not detected in parallel experiments using unfractionated cells or TX100-insoluble fractions
Curated By
- BioGRID