BAIT
PABPC1
PAB1, PABP, PABP1, PABPC2, PABPL1
poly(A) binding protein, cytoplasmic 1
GO Process (17)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- gene silencing by RNA [ISS]
- mRNA metabolic process [TAS]
- mRNA polyadenylation [TAS]
- mRNA splicing, via spliceosome [IC]
- mRNA stabilization [TAS]
- negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IDA]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- nuclear-transcribed mRNA poly(A) tail shortening [TAS]
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISS]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [ISS]
- positive regulation of translation [TAS]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LHX1
LIM-1, LIM1
LIM homeobox 1
GO Process (50)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- S-shaped body morphogenesis [ISS]
- anatomical structure formation involved in morphogenesis [ISS]
- anatomical structure morphogenesis [ISS]
- anterior/posterior axis specification [ISS]
- anterior/posterior pattern specification [ISS]
- cell-cell signaling [ISS]
- cerebellar Purkinje cell differentiation [ISS]
- cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation [ISS]
- cerebellum development [ISS]
- cervix development [ISS]
- comma-shaped body morphogenesis [ISS]
- dorsal/ventral pattern formation [ISS]
- ectoderm formation [ISS]
- embryonic pattern specification [ISS]
- embryonic retina morphogenesis in camera-type eye [ISS]
- embryonic viscerocranium morphogenesis [ISS]
- endoderm formation [ISS]
- epithelium development [ISS]
- forebrain regionalization [ISS]
- gastrulation with mouth forming second [ISS]
- head development [ISS]
- kidney development [ISS]
- lateral motor column neuron migration [ISS]
- motor neuron axon guidance [ISS]
- negative regulation of transcription, DNA-templated [ISS]
- nephric duct morphogenesis [ISS]
- nervous system development [TAS]
- organ morphogenesis [TAS]
- oviduct development [ISS]
- oviduct epithelium development [ISS]
- paramesonephric duct development [ISS]
- pattern specification process [ISS]
- positive regulation of anterior head development [ISS]
- positive regulation of branching involved in ureteric bud morphogenesis [ISS]
- positive regulation of embryonic development [ISS]
- positive regulation of gastrulation [ISS]
- positive regulation of nephron tubule epithelial cell differentiation [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- post-embryonic development [ISS]
- primitive streak formation [ISS]
- regulation of gene expression [ISS]
- renal vesicle morphogenesis [ISS]
- retina layer formation [ISS]
- spinal cord association neuron differentiation [ISS]
- transcription from RNA polymerase II promoter [ISS]
- ureteric bud development [ISS]
- urogenital system development [ISS]
- uterine epithelium development [ISS]
- uterus development [ISS]
- vagina development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Cells organize their actions partly through tightly controlled protein-protein interactions-collectively termed the interactome. Here we use crosslinking mass spectrometry (XL-MS) to chart the protein-protein interactions in intact human nuclei. Overall, we identified ∼8,700 crosslinks, of which 2/3 represent links connecting distinct proteins. From these data, we gain insights on interactions involving histone proteins. We observed that core histones on the ... [more]
Mol. Cell Proteomics Dec. 01, 2017; 17(10);2018-2033 [Pubmed: 30021884]
Throughput
- High Throughput
Additional Notes
- interaction identified using XL-MS (cross-linking mass spectrometry): TX100-insoluble fractions from cells were treated with cross-linker and cross-linked proteins were identified by mass-spectrometry; interaction is undirectional; therefore bait and prey/hit have been assigned arbitrarily; interactions with FDRs (false discovery rates) of 1% or less were reported; this interaction was not detected in parallel experiments using unfractionated cells or TX100-soluble fractions
Curated By
- BioGRID