BAIT
NRG1
ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF
neuregulin 1
GO Process (33)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- ERBB signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- activation of transmembrane receptor protein tyrosine kinase activity [IDA, NAS]
- cardiac muscle cell differentiation [ISS]
- cardiac muscle cell myoblast differentiation [IDA]
- cell communication [TAS]
- cell proliferation [IDA]
- cellular protein complex disassembly [IGI]
- endocardial cell differentiation [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- intracellular signal transduction [IBA]
- mammary gland development [TAS]
- negative regulation of cardiac muscle cell apoptotic process [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of secretion [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- nervous system development [TAS]
- neural crest cell development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of cardiac muscle cell proliferation [IDA]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of striated muscle cell differentiation [ISS]
- regulation of protein heterodimerization activity [IDA]
- regulation of protein homodimerization activity [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
- ventricular cardiac muscle cell differentiation [IDA]
- ventricular trabecula myocardium morphogenesis [IDA]
- wound healing [IDA, TAS]
Gene Ontology Molecular Function- ErbB-3 class receptor binding [IDA, IPI]
- cytokine activity [TAS]
- growth factor activity [IDA, NAS]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor binding [IPI]
- receptor tyrosine kinase binding [NAS]
- transcription cofactor activity [IDA]
- transmembrane receptor protein tyrosine kinase activator activity [IC, NAS]
- ErbB-3 class receptor binding [IDA, IPI]
- cytokine activity [TAS]
- growth factor activity [IDA, NAS]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor binding [IPI]
- receptor tyrosine kinase binding [NAS]
- transcription cofactor activity [IDA]
- transmembrane receptor protein tyrosine kinase activator activity [IC, NAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
HIST1H2BH
H2B/j, H2BFJ
histone cluster 1, H2bh
GO Process (2)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Cells organize their actions partly through tightly controlled protein-protein interactions-collectively termed the interactome. Here we use crosslinking mass spectrometry (XL-MS) to chart the protein-protein interactions in intact human nuclei. Overall, we identified ∼8,700 crosslinks, of which 2/3 represent links connecting distinct proteins. From these data, we gain insights on interactions involving histone proteins. We observed that core histones on the ... [more]
Mol. Cell Proteomics Dec. 01, 2017; 17(10);2018-2033 [Pubmed: 30021884]
Throughput
- High Throughput
Additional Notes
- interaction identified using XL-MS (cross-linking mass spectrometry): TX100-insoluble fractions from cells were treated with cross-linker and cross-linked proteins were identified by mass-spectrometry; interaction is undirectional; therefore bait and prey/hit have been assigned arbitrarily; interactions with FDRs (false discovery rates) of 1% or less were reported; this interaction was not detected in parallel experiments using unfractionated cells or TX100-soluble fractions
Curated By
- BioGRID