OPRM1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- behavioral response to ethanol [IMP]
- cellular response to morphine [IBA]
- cellular response to stress [IMP]
- negative regulation of Wnt protein secretion [IMP]
- negative regulation of adenylate cyclase activity [ISS]
- negative regulation of cAMP-mediated signaling [IDA]
- negative regulation of cell proliferation [TAS]
- negative regulation of cytosolic calcium ion concentration [IDA]
- negative regulation of nitric oxide biosynthetic process [IDA]
- neuropeptide signaling pathway [IMP]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of cAMP-mediated signaling [IDA]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of neurogenesis [ISS]
- positive regulation of nitric oxide biosynthetic process [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- sensory perception [NAS]
- sensory perception of pain [IBA, ISS]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
OPRL1
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [IMP]
- neuropeptide signaling pathway [IBA]
- opioid receptor signaling pathway [IDA]
- positive regulation of cytosolic calcium ion concentration [IGI]
- sensory perception [TAS]
- sensory perception of pain [IBA, ISS]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist.
Nociceptin activation of ORL1 (opioid receptor-like 1 receptor) has been shown to antagonize mu receptor-mediated analgesia at the supraspinal level. ORL1 and mu-opioid receptor (muR) are co-expressed in several subpopulations of CNS neurons involved in regulating pain transmission. The amino acid sequence of ORL1 also shares a high degree of homology with that of mu receptor. Thus, it is hypothesized ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| OPRL1 OPRM1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| OPRM1 OPRL1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| OPRL1 OPRM1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID