BAIT
MN1
MGCR, MGCR1, MGCR1-PEN, dJ353E16.2, CTA-437G10__B.1
meningioma (disrupted in balanced translocation) 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
TNPO1
IPO2, KPNB2, MIP, MIP1, TRN
transportin 1
GO Process (4)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities.
MN1 was originally identified as a tumor-suppressor gene. Knockout mouse studies have suggested that Mn1 is associated with craniofacial development. However, no MN1-related phenotypes have been established in humans. Here, we report on three individuals who have de novo MN1 variants that lead to a protein lacking the carboxyl (C) terminus and who presented with severe developmental delay, craniofacial abnormalities ... [more]
Am. J. Hum. Genet. Dec. 02, 2019; 106(1);13-25 [Pubmed: 31839203]
Throughput
- High Throughput
Curated By
- BioGRID