BAIT
PMEPA1
STAG1, TMEPAI, RP4-718J7.3
prostate transmembrane protein, androgen induced 1
GO Process (5)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- androgen receptor signaling pathway [NAS]
- negative regulation of SMAD protein complex assembly [IDA]
- negative regulation of pathway-restricted SMAD protein phosphorylation [IDA, IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA, IMP, TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
VDAC1
PORIN, VDAC-1
voltage-dependent anion channel 1
GO Process (2)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1.
The Hippo signaling pathway controls organ development and is also known, in cancer, to have a tumor suppressing role. Within the Hippo pathway, we here demonstrate, in human gliomas, a functional interaction of a transmembrane protein, prostate transmembrane protein, androgen induced 1 (PMEPA1) with large tumor suppressor kinase 1 (LATS1). We show that PMEPA1 is upregulated in primary human gliomas. ... [more]
Oncogene Jan. 01, 2020; 39(5);1125-1139 [Pubmed: 31605013]
Throughput
- High Throughput
Curated By
- BioGRID