CDH23
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- auditory receptor cell differentiation [IMP]
- auditory receptor cell stereocilium organization [IGI, IMP]
- calcium ion transport [ISO]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- cell adhesion [TAS]
- cytosolic calcium ion homeostasis [ISO]
- equilibrioception [ISO]
- inner ear development [IMP]
- inner ear morphogenesis [IMP]
- locomotory behavior [IMP]
- photoreceptor cell maintenance [ISO]
- post-embryonic organ morphogenesis [IMP]
- righting reflex [IMP]
- sensory perception of light stimulus [IMP, ISO]
- sensory perception of sound [IGI, IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
USH1C
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [ISO]
- actin filament bundle assembly [IDA]
- auditory receptor cell differentiation [IMP]
- equilibrioception [ISO]
- inner ear morphogenesis [IMP]
- neuromuscular process controlling balance [IMP]
- parallel actin filament bundle assembly [IDA]
- photoreceptor cell maintenance [ISO]
- sensory perception of light stimulus [ISO]
- sensory perception of sound [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Photoreceptor expression of the Usher syndrome type 1 protein protocadherin 15 (USH1F) and its interaction with the scaffold protein harmonin (USH1C).
PURPOSE: The human Usher syndrome (USH) is the most common form of deaf-blindness. Usher type I (USH1), the most severe form, is characterized by profound congenital deafness, constant vestibular dysfunction and prepubertal onset of retinitis pigmentosa. Five corresponding genes of the seven USH1 genes have been cloned over the years. Recent studies indicated that three USH1 proteins, namely myosin VIIa ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| USH1C CDH23 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| USH1C CDH23 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID