BAIT
SOX2
Sox-2, lcc, ysb, AL606746.1
SRY (sex determining region Y)-box 2
GO Process (53)
GO Function (12)
GO Component (6)
Gene Ontology Biological Process
- adenohypophysis development [IMP]
- anatomical structure formation involved in morphogenesis [IMP]
- cell cycle arrest [ISO]
- cell fate commitment [IDA]
- cell fate specification [IMP]
- cerebral cortex development [IMP]
- detection of mechanical stimulus involved in equilibrioception [IMP]
- detection of mechanical stimulus involved in sensory perception of sound [IMP]
- diencephalon morphogenesis [IMP]
- embryonic organ development [IMP]
- endodermal cell fate specification [ISO]
- epithelial tube branching involved in lung morphogenesis [IDA]
- forebrain neuron differentiation [IMP]
- inner ear morphogenesis [IMP]
- lens induction in camera-type eye [IGI]
- lung alveolus development [IDA]
- male genitalia development [IMP]
- negative regulation of Wnt signaling pathway [IGI]
- negative regulation of canonical Wnt signaling pathway [IDA, ISO]
- negative regulation of cell differentiation [IMP]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of neuron differentiation [IDA]
- negative regulation of osteoblast differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- neuron fate commitment [IMP]
- neuronal stem cell maintenance [IGI]
- olfactory placode formation [IGI]
- osteoblast differentiation [ISO]
- pigment biosynthetic process [IMP]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Notch signaling pathway [IDA]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell-cell adhesion [ISO]
- positive regulation of epithelial cell differentiation [IDA]
- positive regulation of neuroblast proliferation [IMP]
- positive regulation of neuron differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- regulation of gene expression [ISO]
- regulation of neurogenesis [IGI]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA, ISO]
- response to growth factor [ISO]
- response to organic substance [IDA]
- response to retinoic acid [IDA]
- retina morphogenesis in camera-type eye [IMP]
- sensory perception of sound [IMP]
- somatic stem cell maintenance [ISO]
- stem cell differentiation [IDA]
- stem cell maintenance [IMP]
- tongue development [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, IGI, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- miRNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA, ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
- DNA binding [IDA, IGI, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- miRNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA, ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
HSPA8
2410008N15Rik, Hsc70, Hsc71, Hsc73, Hsp73, Hspa10
heat shock protein 8
GO Process (10)
GO Function (13)
GO Component (18)
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO]
- chaperone mediated protein folding requiring cofactor [IGI, ISO]
- chaperone-mediated protein folding [ISO]
- clathrin coat disassembly [IGI]
- negative regulation of fibril organization [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of mRNA splicing, via spliceosome [IMP]
- protein folding [IDA]
- protein refolding [ISO]
- regulation of cell cycle [IDA]
Gene Ontology Molecular Function- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [IDA, ISO]
- G-protein coupled receptor binding [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [IPI, ISO]
- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [IDA, ISO]
- G-protein coupled receptor binding [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [IPI, ISO]
Gene Ontology Cellular Component
- Prp19 complex [ISO]
- blood microparticle [ISO]
- cytoplasm [ISO]
- cytosol [IDA, ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [IDA, ISO]
- focal adhesion [ISO]
- intracellular [IDA]
- membrane [ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- protein complex [ISO]
- ribonucleoprotein complex [ISO]
- synaptic vesicle [ISO]
- terminal bouton [ISO]
- ubiquitin ligase complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.
Sox2 is a master transcriptional regulator of embryonic development. In this study, we determined the protein interactome of Sox2 in the chromatin and nucleoplasm of mouse embryonic stem (mES) cells. Apart from canonical interactions with pluripotency-regulating transcription factors, we identified interactions with several chromatin modulators, including members of the heterochromatin protein 1 (HP1) family, suggesting a role for Sox2 in ... [more]
Exp. Cell Res. Dec. 01, 2018; 381(1);129-138 [Pubmed: 31077711]
Throughput
- High Throughput
Curated By
- BioGRID