SOX2
Gene Ontology Biological Process
- adenohypophysis development [IMP]
- anatomical structure formation involved in morphogenesis [IMP]
- cell cycle arrest [ISO]
- cell fate commitment [IDA]
- cell fate specification [IMP]
- cerebral cortex development [IMP]
- detection of mechanical stimulus involved in equilibrioception [IMP]
- detection of mechanical stimulus involved in sensory perception of sound [IMP]
- diencephalon morphogenesis [IMP]
- embryonic organ development [IMP]
- endodermal cell fate specification [ISO]
- epithelial tube branching involved in lung morphogenesis [IDA]
- forebrain neuron differentiation [IMP]
- inner ear morphogenesis [IMP]
- lens induction in camera-type eye [IGI]
- lung alveolus development [IDA]
- male genitalia development [IMP]
- negative regulation of Wnt signaling pathway [IGI]
- negative regulation of canonical Wnt signaling pathway [IDA, ISO]
- negative regulation of cell differentiation [IMP]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of neuron differentiation [IDA]
- negative regulation of osteoblast differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- neuron fate commitment [IMP]
- neuronal stem cell maintenance [IGI]
- olfactory placode formation [IGI]
- osteoblast differentiation [ISO]
- pigment biosynthetic process [IMP]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Notch signaling pathway [IDA]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell-cell adhesion [ISO]
- positive regulation of epithelial cell differentiation [IDA]
- positive regulation of neuroblast proliferation [IMP]
- positive regulation of neuron differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- regulation of gene expression [ISO]
- regulation of neurogenesis [IGI]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA, ISO]
- response to growth factor [ISO]
- response to organic substance [IDA]
- response to retinoic acid [IDA]
- retina morphogenesis in camera-type eye [IMP]
- sensory perception of sound [IMP]
- somatic stem cell maintenance [ISO]
- stem cell differentiation [IDA]
- stem cell maintenance [IMP]
- tongue development [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, IGI, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- miRNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA, ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
- DNA binding [IDA, IGI, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- miRNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA, ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
Gene Ontology Cellular Component
OGT
Gene Ontology Biological Process
- apoptotic process [ISO]
- cellular response to glucose stimulus [ISO]
- cellular response to lipopolysaccharide [ISO]
- cellular response to retinoic acid [ISO]
- circadian regulation of gene expression [IMP]
- glucosamine metabolic process [ISO]
- histone H3-K4 trimethylation [ISO]
- histone H4-K16 acetylation [ISO]
- histone H4-K5 acetylation [ISO]
- histone H4-K8 acetylation [ISO]
- intracellular distribution of mitochondria [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cellular response to hypoxia [ISO]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of peptidyl-threonine phosphorylation [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of protein targeting to membrane [ISO]
- negative regulation of protein ubiquitination [IDA]
- phosphatidylinositol-mediated signaling [ISO]
- positive regulation of catalytic activity [ISO]
- positive regulation of cell size [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of granulocyte differentiation [ISO]
- positive regulation of histone H3-K27 methylation [ISO]
- positive regulation of histone H3-K4 methylation [ISO]
- positive regulation of protein localization to nucleus [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of proteolysis [ISO]
- positive regulation of reactive oxygen species biosynthetic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein O-linked glycosylation [IDA, ISO, ISS, TAS]
- protein heterotrimerization [ISO]
- protein homotrimerization [ISO]
- regulation of Rac protein signal transduction [ISO]
- regulation of gluconeogenesis involved in cellular glucose homeostasis [IMP]
- regulation of glycolytic process [ISO]
- regulation of insulin receptor signaling pathway [ISO]
- response to insulin [ISO]
Gene Ontology Molecular Function- N-acetyltransferase activity [TAS]
- catalytic activity [ISS]
- enzyme activator activity [ISO]
- histone acetyltransferase activity (H4-K16 specific) [ISO]
- histone acetyltransferase activity (H4-K5 specific) [ISO]
- histone acetyltransferase activity (H4-K8 specific) [ISO]
- monosaccharide binding [ISO]
- peptide binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- protein N-acetylglucosaminyltransferase activity [ISO]
- protein O-GlcNAc transferase activity [IDA, IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- transcription factor binding [ISO]
- N-acetyltransferase activity [TAS]
- catalytic activity [ISS]
- enzyme activator activity [ISO]
- histone acetyltransferase activity (H4-K16 specific) [ISO]
- histone acetyltransferase activity (H4-K5 specific) [ISO]
- histone acetyltransferase activity (H4-K8 specific) [ISO]
- monosaccharide binding [ISO]
- peptide binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- protein N-acetylglucosaminyltransferase activity [ISO]
- protein O-GlcNAc transferase activity [IDA, IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- MLL5-L complex [ISO]
- cytoplasm [ISO, TAS]
- cytosol [ISO]
- euchromatin [ISO]
- histone acetyltransferase complex [ISO]
- intracellular [TAS]
- microtubule organizing center [ISO]
- mitochondrion [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [ISO, TAS]
- plasma membrane [ISO]
- zymogen granule [ISO]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.
Sox2 is a master transcriptional regulator of embryonic development. In this study, we determined the protein interactome of Sox2 in the chromatin and nucleoplasm of mouse embryonic stem (mES) cells. Apart from canonical interactions with pluripotency-regulating transcription factors, we identified interactions with several chromatin modulators, including members of the heterochromatin protein 1 (HP1) family, suggesting a role for Sox2 in ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SOX2 OGT | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| OGT SOX2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID