BAIT
IGFBP3
BP-53, IBP3, tcag7.703
insulin-like growth factor binding protein 3
GO Process (11)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- negative regulation of cell proliferation [IGI]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of signal transduction [NAS]
- negative regulation of smooth muscle cell migration [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of catalytic activity [IDA]
- positive regulation of myoblast differentiation [IDA]
- protein phosphorylation [IDA]
- regulation of insulin-like growth factor receptor signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KRT19
CK19, K19, K1CS
keratin 19
GO Process (2)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
IGFBP-3 interacts with NONO and SFPQ in PARP-dependent DNA damage repair in triple-negative breast cancer.
Women with triple-negative breast cancer (TNBC) are generally treated by chemotherapy but their responsiveness may be blunted by DNA double-strand break (DSB) repair. We previously reported that IGFBP-3 forms nuclear complexes with EGFR and DNA-dependent protein kinase (DNA-PKcs) to modulate DSB repair by non-homologous end-joining (NHEJ) in TNBC cells. To discover IGFBP-3 binding partners involved in chemoresistance through stimulation of ... [more]
Cell. Mol. Life Sci. May. 01, 2019; 76(10);2015-2030 [Pubmed: 30725116]
Throughput
- High Throughput
Curated By
- BioGRID