BAIT
IGFBP3
BP-53, IBP3, tcag7.703
insulin-like growth factor binding protein 3
GO Process (11)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- negative regulation of cell proliferation [IGI]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of signal transduction [NAS]
- negative regulation of smooth muscle cell migration [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of catalytic activity [IDA]
- positive regulation of myoblast differentiation [IDA]
- protein phosphorylation [IDA]
- regulation of insulin-like growth factor receptor signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HNRNPA2B1
HNRNPA2, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, IBMPFD2, RNPA2, SNRPB1
heterogeneous nuclear ribonucleoprotein A2/B1
GO Process (5)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
IGFBP-3 interacts with NONO and SFPQ in PARP-dependent DNA damage repair in triple-negative breast cancer.
Women with triple-negative breast cancer (TNBC) are generally treated by chemotherapy but their responsiveness may be blunted by DNA double-strand break (DSB) repair. We previously reported that IGFBP-3 forms nuclear complexes with EGFR and DNA-dependent protein kinase (DNA-PKcs) to modulate DSB repair by non-homologous end-joining (NHEJ) in TNBC cells. To discover IGFBP-3 binding partners involved in chemoresistance through stimulation of ... [more]
Cell. Mol. Life Sci. May. 01, 2019; 76(10);2015-2030 [Pubmed: 30725116]
Throughput
- High Throughput
Curated By
- BioGRID