SLC1A1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRIN2A
Gene Ontology Biological Process
- action potential [IMP]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cation transmembrane transport [IDA]
- cation transport [IDA]
- cellular response to amino acid stimulus [IMP]
- cellular response to dsRNA [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to lipid [IEP]
- cellular response to magnesium ion [IEP]
- cellular response to manganese ion [IEP]
- cellular response to zinc ion [IMP]
- cerebral cortex development [IEP]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- directional locomotion [ISO]
- dopamine metabolic process [ISO]
- hippocampus development [IEP]
- ion transmembrane transport [IMP, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- learning [ISO]
- learning or memory [ISO]
- locomotion [ISO]
- memory [IDA, ISO]
- negative regulation of protein catabolic process [ISO]
- neurogenesis [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [IDA]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- protein localization [ISO]
- protein tetramerization [IDA]
- regulation of excitatory postsynaptic membrane potential [IMP, ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of membrane potential [ISO]
- regulation of postsynaptic membrane potential [ISO]
- regulation of sensory perception of pain [ISO]
- regulation of synaptic plasticity [ISO]
- regulation of synaptic transmission [ISO]
- response to amine [IEP]
- response to ammonium ion [IEP]
- response to amphetamine [ISO]
- response to calcium ion [IEP]
- response to carbohydrate [IEP]
- response to cocaine [IEP]
- response to drug [IEP, ISO]
- response to ethanol [IEP, ISO]
- response to fungicide [IEP]
- response to light stimulus [IEP]
- response to manganese ion [IEP]
- response to methylmercury [IEP]
- response to organic cyclic compound [IEP]
- response to other organism [IEP]
- response to wounding [ISO]
- rhythmic process [IDA]
- sensory perception of pain [ISO]
- serotonin metabolic process [ISO]
- sleep [ISO]
- spinal cord development [IEP]
- startle response [ISO]
- synaptic transmission [IMP, ISO]
- synaptic transmission, glutamatergic [IBA]
- visual learning [ISO]
Gene Ontology Molecular Function- ATPase binding [IPI]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IMP, ISO]
- calcium channel activity [ISO]
- cation channel activity [IDA, ISO]
- cell adhesion molecule binding [IPI]
- extracellular-glutamate-gated ion channel activity [IMP]
- glutamate binding [IDA, IMP]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor activity [IDA, IMP]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- protein kinase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [IPI]
- voltage-gated cation channel activity [IMP]
- zinc ion binding [IDA, ISS]
- ATPase binding [IPI]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IMP, ISO]
- calcium channel activity [ISO]
- cation channel activity [IDA, ISO]
- cell adhesion molecule binding [IPI]
- extracellular-glutamate-gated ion channel activity [IMP]
- glutamate binding [IDA, IMP]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor activity [IDA, IMP]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- protein kinase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [IPI]
- voltage-gated cation channel activity [IMP]
- zinc ion binding [IDA, ISS]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, ISO]
- cell surface [ISO]
- dendritic spine [IDA]
- endoplasmic reticulum [ISO]
- membrane [ISO]
- neuron projection [IDA, ISO]
- neuronal postsynaptic density [ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IDA, ISO]
- synapse [ISO, TAS]
- synaptic vesicle [ISO]
- terminal bouton [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
N-methyl-D-aspartate receptor-dependent regulation of the glutamate transporter excitatory amino acid carrier 1.
The neuronal transporter excitatory amino acid carrier 1 (EAAC1) is enriched in perisynaptic regions, where it may regulate synaptic spillover of glutamate. In this study we examined potential interactions between EAAC1 and ionotropic glutamate receptors. N-Methyl-D-aspartate (NMDA) receptor subunits NR1, NR2A, and NR2B, but not the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunit GluR2, were co-immunoprecipitated with EAAC1 from neuron-enriched hippocampal cultures. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID