TCF4
Gene Ontology Biological Process
- DNA-templated transcription, initiation [ISS]
- positive regulation of neuron differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- protein-DNA complex assembly [ISS]
- transcription initiation from RNA polymerase II promoter [ISS]
Gene Ontology Molecular Function- DNA binding [IDA]
- E-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- TFIIB-class binding transcription factor activity [ISS]
- TFIIB-class transcription factor binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [ISS, NAS]
- sequence-specific DNA binding RNA polymerase recruiting transcription factor activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- DNA binding [IDA]
- E-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- TFIIB-class binding transcription factor activity [ISS]
- TFIIB-class transcription factor binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [ISS, NAS]
- sequence-specific DNA binding RNA polymerase recruiting transcription factor activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
ID2
Gene Ontology Biological Process
- cellular senescence [ISS]
- circadian regulation of gene expression [ISS]
- embryonic digestive tract morphogenesis [ISS]
- endodermal digestive tract morphogenesis [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- epithelial cell differentiation involved in mammary gland alveolus development [ISS]
- locomotor rhythm [ISS]
- mammary gland alveolus development [ISS]
- mammary gland epithelial cell proliferation [ISS]
- multicellular organismal development [TAS]
- negative regulation of gene expression [ISS]
- negative regulation of neural precursor cell proliferation [ISS]
- negative regulation of neuron differentiation [ISS]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neuron fate commitment [ISS]
- positive regulation of blood pressure [ISS]
- positive regulation of cell cycle arrest [ISS]
- positive regulation of gene expression [ISS]
- positive regulation of smooth muscle cell proliferation [ISS]
- positive regulation of transcription involved in G1/S transition of mitotic cell cycle [IC]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of G1/S transition of mitotic cell cycle [IMP]
- regulation of circadian rhythm [ISS]
- regulation of lipid metabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Determinants of helix-loop-helix dimerization affinity. Random mutational analysis of SCL/tal.
Dimerization represents a key regulatory step in the function of basic helix-loop-helix transcriptional factors. In many instances tissue-specific basic helix-loop-helix proteins, such as the hematopoietic factor SCL/tal or the myogenic factor MyoD, interact with ubiquitously expressed basic helix-loop-helix proteins, such as E2A or E2-2. Such dimerization is necessary for high affinity, sequence-specific DNA binding. Previous biochemical and structural studies have ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ID2 TCF4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2218649 | |
| TCF4 ID2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3294505 | |
| ID2 TCF4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3106857 | |
| TCF4 ID2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 1506548 | |
| TCF4 ID2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - | |
| ID2 TCF4 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - | |
| TCF4 ID2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID