CIB1
Gene Ontology Biological Process
- apoptotic process [IMP]
- cellular response to DNA damage stimulus [IDA]
- cellular response to growth factor stimulus [ISS]
- cellular response to nerve growth factor stimulus [IDA]
- cellular response to tumor necrosis factor [IMP]
- cytoplasmic microtubule organization [IMP]
- double-strand break repair [TAS]
- endomitotic cell cycle [IDA]
- extrinsic apoptotic signaling pathway [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of megakaryocyte differentiation [ISS]
- negative regulation of microtubule depolymerization [IDA]
- negative regulation of neuron projection development [IDA]
- negative regulation of protein kinase B signaling [ISS]
- negative regulation of protein phosphorylation [ISS]
- platelet formation [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of calcineurin-NFAT signaling cascade [IDA]
- positive regulation of cell adhesion mediated by integrin [IDA]
- positive regulation of cell growth [ISS]
- positive regulation of cell migration [ISS]
- positive regulation of cell migration involved in sprouting angiogenesis [ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of cell-matrix adhesion [ISS]
- positive regulation of establishment of protein localization to plasma membrane [IGI]
- positive regulation of male germ cell proliferation [ISS]
- positive regulation of metalloenzyme activity [ISS]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of protein serine/threonine kinase activity [ISS]
- positive regulation of protein targeting to membrane [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IDA]
- regulation of cell division [IMP]
- regulation of cell proliferation [IMP]
- response to ischemia [ISS]
- spermatid development [ISS]
- thrombopoietin-mediated signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell periphery [IDA]
- centrosome [IDA]
- cytoplasm [IDA, IMP]
- endoplasmic reticulum [IMP]
- extracellular vesicular exosome [IDA]
- filopodium tip [IDA]
- growth cone [IDA]
- lamellipodium [IDA]
- membrane [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleoplasm [IDA, IMP]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- sarcolemma [IDA]
- vesicle [IDA]
RAC3
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- actin cytoskeleton organization [IDA]
- cell projection assembly [IDA]
- intracellular signal transduction [TAS]
- positive regulation of cell adhesion mediated by integrin [IDA]
- positive regulation of substrate adhesion-dependent cell spreading [IDA]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading.
There are only three human isoforms of the small GTPase Rac, which together regulate a variety of cellular processes, including those related to actin cytoskeletal reorganization. A role for Rac3 in integrin-mediated adhesion and spreading has not been defined. We here report that CIB, a protein that binds to the alpha(IIb)beta(3) fibrinogen receptor, interacts exclusively with activated (V12) Rac3 but ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAC3 CIB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| RAC3 CIB1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID