PKP2
Gene Ontology Biological Process
- adherens junction maintenance [ISS]
- bundle of His cell to Purkinje myocyte communication [IMP]
- cardiac muscle cell action potential [ISS]
- cardiac muscle cell action potential involved in contraction [IMP]
- cell communication by electrical coupling involved in cardiac conduction [ISS]
- cell-cell signaling involved in cardiac conduction [IMP]
- desmosome assembly [IMP]
- gap junction assembly [ISS]
- heart development [ISS]
- intermediate filament bundle assembly [IMP]
- lipid homeostasis [ISS]
- maintenance of organ identity [IMP]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [ISS]
- positive regulation of sodium ion transport [ISS]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of tight junction assembly [ISS]
- single organismal cell-cell adhesion [ISS, NAS]
- ventricular cardiac muscle cell action potential [IMP]
- ventricular cardiac muscle tissue morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DSP
Gene Ontology Biological Process
- apoptotic process [TAS]
- bundle of His cell to Purkinje myocyte communication [IMP]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- desmosome organization [ISS]
- epidermis development [TAS]
- intermediate filament organization [ISS]
- keratinocyte differentiation [IDA]
- peptide cross-linking [IDA]
- protein localization to adherens junction [ISS]
- regulation of heart rate by cardiac conduction [IMP]
- ventricular cardiac muscle cell action potential [IMP]
- ventricular compact myocardium morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.
Plakophilins are a subfamily of p120-related arm-repeat proteins that can be found in both desmosomes and the nucleus. Among the three known plakophilin members, plakophilin 1 has been linked to a genetic skin disorder and shown to play important roles in desmosome assembly and organization. However, little is known about the binding partners and functions of the most widely expressed ... [more]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID