BAIT
BCAR1
CAS, CAS1, CASS1, CRKAS, P130Cas, hCG_1980470
breast cancer anti-estrogen resistance 1
GO Process (23)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IDA]
- G-protein coupled receptor signaling pathway [ISS, NAS]
- T cell receptor signaling pathway [NAS]
- actin filament organization [IDA]
- antigen receptor-mediated signaling pathway [IDA]
- blood coagulation [TAS]
- cell chemotaxis [IMP]
- cell division [NAS]
- cell migration [IDA]
- cell proliferation [TAS]
- cellular response to hepatocyte growth factor stimulus [IMP]
- epidermal growth factor receptor signaling pathway [ISS]
- hepatocyte growth factor receptor signaling pathway [IMP]
- insulin receptor signaling pathway [ISS]
- integrin-mediated signaling pathway [IDA]
- neurotrophin TRK receptor signaling pathway [ISS]
- platelet activation [TAS]
- platelet-derived growth factor receptor signaling pathway [ISS]
- positive regulation of cell migration [IDA]
- positive regulation of endothelial cell migration [IDA]
- regulation of apoptotic process [TAS]
- regulation of cell growth [TAS]
- vascular endothelial growth factor receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
HCK
JTK9, p59Hck, p61Hck, RP5-836N17.3
HCK proto-oncogene, Src family tyrosine kinase
GO Process (30)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- cell adhesion [TAS]
- cell differentiation [IBA]
- cellular response to peptide hormone stimulus [IBA]
- cytokine-mediated signaling pathway [TAS]
- innate immune response [IBA, TAS]
- innate immune response-activating signal transduction [TAS]
- integrin-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte degranulation [TAS]
- leukocyte migration involved in immune response [TAS]
- lipopolysaccharide-mediated signaling pathway [TAS]
- mesoderm development [TAS]
- negative regulation of apoptotic process [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of actin cytoskeleton reorganization [IDA, IMP]
- positive regulation of actin filament polymerization [TAS]
- positive regulation of cell proliferation [IMP]
- protein autophosphorylation [IMP]
- protein phosphorylation [TAS]
- regulation of cell shape [IMP]
- regulation of defense response to virus by virus [TAS]
- regulation of inflammatory response [TAS]
- regulation of phagocytosis [IMP]
- regulation of podosome assembly [IDA]
- regulation of sequence-specific DNA binding transcription factor activity [IMP]
- respiratory burst after phagocytosis [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.
The Crk-associated substrate p130(Cas) (Cas) and the recently described human enhancer of filamentation 1 (HEF1) are two proteins with similar structure (64% amino acid homology), which are thought to act as "docking" molecules in intracellular signaling cascades. Both proteins contain an N-terminal Src homology (SH), three domain and a cluster of SH2 binding motifs. Here we show that ligation of ... [more]
J. Biol. Chem. Feb. 14, 1997; 272(7);4230-6 [Pubmed: 9020138]
Throughput
- Low Throughput
Curated By
- BioGRID