Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

alpha2-Macroglobulin, the main serum antiprotease, binds beta2-microglobulin, the light chain of the class I major histocompatibility complex, which is involved in human disease.

Gouin-Charnet A, Laune D, Granier C, Mani JC, Pau B, Mourad G, Argiles A

beta(2)-Microglobulin, a 12 kDa protein forming part of the class I HLA (histocompatibility locus antigen) major histocompatibility complex, has been used as a prognosis factor for multiple myeloma and as a marker of renal function, and has been shown to be involved in the pathogenesis of dialysis-related amyloidosis. alpha(2)-Macroglobulin has the ability to bind a wide range of physiologically important ... [more]

Clin. Sci. Apr. 01, 2000; 98(4);427-33 [Pubmed: 10731476]

Throughput

  • Low Throughput

Curated By

  • BioGRID