BAIT
SHH
HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS, tcag7.582
sonic hedgehog
GO Process (70)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [IDA]
- T cell differentiation in thymus [ISS]
- androgen metabolic process [ISS]
- apoptotic signaling pathway [ISS]
- axon guidance [ISS]
- branching involved in ureteric bud morphogenesis [ISS]
- branching morphogenesis of an epithelial tube [ISS]
- cell development [ISS]
- cell fate specification [ISS]
- cell-cell signaling [ISS]
- central nervous system development [ISS]
- cerebellar granule cell precursor proliferation [ISS]
- determination of left/right asymmetry in lateral mesoderm [ISS]
- dorsal/ventral pattern formation [ISS]
- embryo development [ISS]
- embryonic digit morphogenesis [ISS]
- embryonic limb morphogenesis [ISS]
- embryonic pattern specification [TAS]
- epithelial-mesenchymal signaling involved in prostate gland development [IDA]
- forebrain development [ISS]
- heart development [ISS]
- heart looping [ISS]
- hindbrain development [ISS]
- lung development [ISS]
- lymphoid progenitor cell differentiation [IMP]
- male genitalia development [ISS]
- metanephric mesenchymal cell proliferation involved in metanephros development [ISS]
- metanephros development [ISS]
- midbrain development [ISS]
- negative regulation of apoptotic process [ISS]
- negative regulation of cell differentiation [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of cholesterol efflux [ISS]
- negative regulation of kidney smooth muscle cell differentiation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- negative regulation of ureter smooth muscle cell differentiation [ISS]
- negative thymic T cell selection [ISS]
- neural crest cell migration [ISS]
- neuroblast proliferation [ISS]
- neuron fate commitment [ISS]
- pattern specification process [ISS]
- patterning of blood vessels [ISS]
- polarity specification of anterior/posterior axis [ISS]
- positive regulation of T cell differentiation in thymus [ISS]
- positive regulation of alpha-beta T cell differentiation [ISS]
- positive regulation of cell division [IDA]
- positive regulation of cell proliferation [IDA, ISS]
- positive regulation of hh target transcription factor activity [ISS]
- positive regulation of immature T cell proliferation in thymus [ISS]
- positive regulation of kidney smooth muscle cell differentiation [ISS]
- positive regulation of mesenchymal cell proliferation involved in ureter development [ISS]
- positive regulation of sclerotome development [IDA]
- positive regulation of smoothened signaling pathway [IDA, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of ureter smooth muscle cell differentiation [ISS]
- positive thymic T cell selection [ISS]
- prostate gland development [ISS]
- regulation of cell proliferation [ISS]
- regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [NAS]
- regulation of odontogenesis [ISS]
- regulation of protein localization to nucleus [IDA]
- regulation of proteolysis [ISS]
- renal system development [IEP]
- smoothened signaling pathway [IEP, ISS]
- somite development [ISS]
- stem cell development [ISS]
- thymus development [ISS]
- vasculogenesis [ISS]
- ventral midline development [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SHH
HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS, tcag7.582
sonic hedgehog
GO Process (70)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [IDA]
- T cell differentiation in thymus [ISS]
- androgen metabolic process [ISS]
- apoptotic signaling pathway [ISS]
- axon guidance [ISS]
- branching involved in ureteric bud morphogenesis [ISS]
- branching morphogenesis of an epithelial tube [ISS]
- cell development [ISS]
- cell fate specification [ISS]
- cell-cell signaling [ISS]
- central nervous system development [ISS]
- cerebellar granule cell precursor proliferation [ISS]
- determination of left/right asymmetry in lateral mesoderm [ISS]
- dorsal/ventral pattern formation [ISS]
- embryo development [ISS]
- embryonic digit morphogenesis [ISS]
- embryonic limb morphogenesis [ISS]
- embryonic pattern specification [TAS]
- epithelial-mesenchymal signaling involved in prostate gland development [IDA]
- forebrain development [ISS]
- heart development [ISS]
- heart looping [ISS]
- hindbrain development [ISS]
- lung development [ISS]
- lymphoid progenitor cell differentiation [IMP]
- male genitalia development [ISS]
- metanephric mesenchymal cell proliferation involved in metanephros development [ISS]
- metanephros development [ISS]
- midbrain development [ISS]
- negative regulation of apoptotic process [ISS]
- negative regulation of cell differentiation [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of cholesterol efflux [ISS]
- negative regulation of kidney smooth muscle cell differentiation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- negative regulation of ureter smooth muscle cell differentiation [ISS]
- negative thymic T cell selection [ISS]
- neural crest cell migration [ISS]
- neuroblast proliferation [ISS]
- neuron fate commitment [ISS]
- pattern specification process [ISS]
- patterning of blood vessels [ISS]
- polarity specification of anterior/posterior axis [ISS]
- positive regulation of T cell differentiation in thymus [ISS]
- positive regulation of alpha-beta T cell differentiation [ISS]
- positive regulation of cell division [IDA]
- positive regulation of cell proliferation [IDA, ISS]
- positive regulation of hh target transcription factor activity [ISS]
- positive regulation of immature T cell proliferation in thymus [ISS]
- positive regulation of kidney smooth muscle cell differentiation [ISS]
- positive regulation of mesenchymal cell proliferation involved in ureter development [ISS]
- positive regulation of sclerotome development [IDA]
- positive regulation of smoothened signaling pathway [IDA, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of ureter smooth muscle cell differentiation [ISS]
- positive thymic T cell selection [ISS]
- prostate gland development [ISS]
- regulation of cell proliferation [ISS]
- regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [NAS]
- regulation of odontogenesis [ISS]
- regulation of protein localization to nucleus [IDA]
- regulation of proteolysis [ISS]
- renal system development [IEP]
- smoothened signaling pathway [IEP, ISS]
- somite development [ISS]
- stem cell development [ISS]
- thymus development [ISS]
- vasculogenesis [ISS]
- ventral midline development [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
A freely diffusible form of Sonic hedgehog mediates long-range signalling.
The secreted protein Sonic hedgehog (Shh) exerts many of its patterning effects through a combination of short- and long-range signalling. Three distinct mechanisms, which are not necessarily mutually exclusive, have been proposed to account for the long-range effects of Shh: simple diffusion of Shh, a relay mechanism in which Shh activates secondary signals, and direct delivery of Shh through cytoplasmic ... [more]
Nature Jun. 07, 2001; 411(6838);716-20 [Pubmed: 11395778]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SHH SHH | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID