HOXA1
Gene Ontology Biological Process
- abducens nerve formation [IMP]
- anatomical structure morphogenesis [IMP]
- artery development [IMP]
- artery morphogenesis [IMP]
- cochlea development [IMP]
- cochlea morphogenesis [IMP]
- cognition [IDA]
- embryonic neurocranium morphogenesis [IMP]
- inner ear development [IMP]
- multicellular organismal development [TAS]
- neuromuscular process [IDA]
- optokinetic behavior [IDA]
- outer ear morphogenesis [IDA]
- regulation of behavior [IDA]
- semicircular canal formation [IMP]
- sensory perception of sound [IDA]
Gene Ontology Molecular Function
PKNOX1
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
A conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1.
HOX proteins are dependent upon cofactors of the PBX family for specificity of DNA binding. Two regions that have been implicated in HOX/PBX cooperative interactions are the YPWM motif, found N-terminal to the HOX homeodomain, and the GKFQ domain (also known as the Hox cooperativity motif) immediately C-terminal to the PBX homeodomain. Using derivatives of the E2A-PBX oncoprotein, we find ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID