SFRP1
Gene Ontology Biological Process
- canonical Wnt signaling pathway [IDA]
- cellular response to BMP stimulus [IEP]
- cellular response to estradiol stimulus [IEP]
- cellular response to estrogen stimulus [IDA]
- cellular response to fibroblast growth factor stimulus [IDA]
- cellular response to growth factor stimulus [IDA]
- cellular response to heparin [IDA]
- cellular response to hypoxia [IEP]
- cellular response to interleukin-1 [IEP]
- cellular response to prostaglandin E stimulus [IEP]
- cellular response to starvation [IEP]
- cellular response to transforming growth factor beta stimulus [IEP]
- cellular response to tumor necrosis factor [IDA]
- cellular response to vitamin D [IEP]
- dorsal/ventral axis specification [IDA]
- hematopoietic progenitor cell differentiation [IDA]
- hematopoietic stem cell differentiation [IDA]
- menstrual cycle phase [IEP]
- negative regulation of B cell differentiation [IMP]
- negative regulation of Wnt signaling pathway [IDA, IMP]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- negative regulation of androgen receptor signaling pathway [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of bone remodeling [IMP]
- negative regulation of canonical Wnt signaling pathway [IDA, IMP]
- negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of epithelial cell proliferation [IDA]
- negative regulation of epithelial to mesenchymal transition [IDA]
- negative regulation of fibroblast apoptotic process [IDA]
- negative regulation of fibroblast proliferation [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of insulin secretion [IDA]
- negative regulation of ossification [IDA, IMP]
- negative regulation of osteoblast proliferation [IMP]
- negative regulation of peptidyl-tyrosine phosphorylation [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- osteoblast differentiation [IEP]
- positive regulation of Rac GTPase activity [ISS]
- positive regulation of Wnt signaling pathway [IDA]
- positive regulation of apoptotic process [IDA, IMP]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of cell-matrix adhesion [ISS]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- positive regulation of fat cell differentiation [IDA]
- positive regulation of fibroblast apoptotic process [IDA]
- positive regulation of focal adhesion assembly [ISS]
- positive regulation of non-canonical Wnt signaling pathway [IDA]
- positive regulation of smoothened signaling pathway [IMP]
- positive regulation of stress fiber assembly [ISS]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- proteolysis [IMP]
- regulation of angiogenesis [ISS]
- regulation of cell cycle process [IMP]
- response to drug [IDA]
- response to organic cyclic compound [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FZD6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling.
Frizzled related proteins (FRPs) comprise a family of secreted molecules that contain an N-terminal cysteine-rich domain (CRD) highly similar to the CRDs of the frizzled family of membrane-anchored Wnt receptors. FRPs have been shown to interact with Wnt proteins and antagonize Wnt signaling in a Xenopus developmental model. We demonstrated that FRP antagonizes the Wnt-induced increase in uncomplexed beta-catenin in ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FZD6 SFRP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID