ITPR3
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G-protein coupled receptor signaling pathway [ISS]
- activation of phospholipase C activity [TAS]
- blood coagulation [TAS]
- calcium ion transport into cytosol [ISS]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- inositol phosphate-mediated signaling [IDA, ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- protein heterooligomerization [ISS]
- protein homooligomerization [ISS]
- regulation of insulin secretion [TAS]
- response to calcium ion [IDA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical part of cell [ISS]
- brush border [ISS]
- cytoplasm [ISS]
- endoplasmic reticulum [ISS]
- endoplasmic reticulum membrane [IDA, ISS, TAS]
- integral component of plasma membrane [IDA]
- membrane [IDA]
- myelin sheath [ISS]
- neuronal cell body [ISS]
- nuclear outer membrane [ISS]
- plasma membrane [IDA]
- platelet dense tubular network membrane [TAS]
- receptor complex [IDA]
TRPC7
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels.
Homologues of Drosophila Trp (transient receptor potential) form plasma membrane channels that mediate Ca(2+) entry following the activation of phospholipase C by cell surface receptors. Among the seven Trp homologous found in mammals, Trp3 has been shown to interact with and respond to IP(3) receptors (IP(3)Rs) for activation. Here we show that Trp4 and other Trp proteins also interact with ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID