BAIT
SMAD2
JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2
SMAD family member 2
GO Process (28)
GO Function (18)
GO Component (9)
Gene Ontology Biological Process
- SMAD protein complex assembly [IDA]
- activin receptor signaling pathway [IMP]
- anterior/posterior pattern specification [ISS]
- cell fate commitment [ISS]
- common-partner SMAD protein phosphorylation [IDA]
- gastrulation [TAS]
- gene expression [TAS]
- intracellular signal transduction [ISS]
- mesoderm formation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transcription, DNA-templated [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- nodal signaling pathway [IMP]
- palate development [ISS]
- paraxial mesoderm morphogenesis [ISS]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of epithelial to mesenchymal transition [ISS]
- positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS, TAS]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISS]
- primary miRNA processing [TAS]
- regulation of binding [ISS]
- regulation of transforming growth factor beta receptor signaling pathway [IMP]
- response to cholesterol [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [IDA, IMP, TAS]
- zygotic specification of dorsal/ventral axis [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [IPI]
- activating transcription factor binding [IPI]
- co-SMAD binding [IPI]
- double-stranded DNA binding [ISS]
- enhancer binding [IC]
- phosphatase binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transforming growth factor beta receptor binding [IPI]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [IDA]
- type I transforming growth factor beta receptor binding [IPI]
- ubiquitin protein ligase binding [IPI]
- DNA binding [IDA]
- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [IPI]
- activating transcription factor binding [IPI]
- co-SMAD binding [IPI]
- double-stranded DNA binding [ISS]
- enhancer binding [IC]
- phosphatase binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transforming growth factor beta receptor binding [IPI]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [IDA]
- type I transforming growth factor beta receptor binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
MEF2C
C5DELq14.3, DEL5q14.3
myocyte enhancer factor 2C
GO Process (98)
GO Function (12)
GO Component (7)
Gene Ontology Biological Process
- B cell homeostasis [ISS]
- B cell proliferation [ISS]
- B cell receptor signaling pathway [ISS]
- MAPK cascade [IDA, IMP]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- blood vessel development [ISS]
- blood vessel remodeling [ISS]
- cardiac ventricle formation [ISS]
- cell morphogenesis involved in neuron differentiation [ISS]
- cellular response to calcium ion [ISS]
- cellular response to drug [ISS]
- cellular response to fluid shear stress [ISS]
- cellular response to lipopolysaccharide [ISS]
- cellular response to parathyroid hormone stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [IDA]
- cellular response to trichostatin A [ISS]
- chondrocyte differentiation [ISS]
- endochondral ossification [ISS]
- epithelial cell proliferation involved in renal tubule morphogenesis [ISS]
- germinal center formation [ISS]
- glomerulus morphogenesis [ISS]
- heart development [IEP, ISS, NAS]
- heart looping [ISS]
- humoral immune response [ISS]
- innate immune response [TAS]
- learning or memory [ISS]
- melanocyte differentiation [ISS]
- muscle cell differentiation [TAS]
- muscle cell fate determination [ISS]
- muscle organ development [TAS]
- myotube differentiation [IEP]
- negative regulation of gene expression [ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of ossification [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- nephron tubule epithelial cell differentiation [ISS]
- nervous system development [TAS]
- neural crest cell differentiation [ISS]
- neuron development [ISS]
- neuron differentiation [IEP, ISS]
- neuron migration [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- osteoblast differentiation [ISS]
- outflow tract morphogenesis [ISS]
- platelet formation [ISS]
- positive regulation of B cell proliferation [ISS]
- positive regulation of MAP kinase activity [ISS]
- positive regulation of alkaline phosphatase activity [ISS]
- positive regulation of behavioral fear response [ISS]
- positive regulation of bone mineralization [ISS]
- positive regulation of cardiac muscle cell differentiation [IDA]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of macrophage apoptotic process [ISS]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of myoblast differentiation [IMP]
- positive regulation of neuron differentiation [ISS]
- positive regulation of osteoblast differentiation [ISS]
- positive regulation of protein homodimerization activity [ISS]
- positive regulation of skeletal muscle cell differentiation [IDA]
- positive regulation of skeletal muscle tissue development [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- primary heart field specification [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of dendritic spine development [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of germinal center formation [ISS]
- regulation of megakaryocyte differentiation [ISS]
- regulation of neuron apoptotic process [ISS]
- regulation of neurotransmitter secretion [ISS]
- regulation of synapse assembly [ISS]
- regulation of synaptic activity [ISS]
- regulation of synaptic plasticity [ISS]
- regulation of synaptic transmission, glutamatergic [ISS]
- regulation of transcription, DNA-templated [IDA]
- renal tubule morphogenesis [ISS]
- response to ischemia [ISS]
- response to virus [IEP]
- secondary heart field specification [ISS]
- sinoatrial valve morphogenesis [ISS]
- skeletal muscle tissue development [ISS]
- smooth muscle cell differentiation [ISS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transcription from RNA polymerase II promoter [IDA, ISS]
- ventricular cardiac muscle cell differentiation [ISS]
Gene Ontology Molecular Function- AT DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [IPI]
- miRNA binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [ISS]
- AT DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [IPI]
- miRNA binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins.
An emerging theme in transforming growth factor-ss (TGF-ss) signalling is the association of the Smad proteins with diverse groups of transcriptional regulatory proteins. Several Smad cofactors have been identified to date but the diversity of TGF-ss effects on gene transcription suggests that interactions with other co-regulators must occur. In these studies we addressed the possible interaction of Smad proteins with ... [more]
Nucleic Acids Res. Feb. 01, 2001; 29(3);732-42 [Pubmed: 11160896]
Throughput
- Low Throughput
Curated By
- BioGRID