CD44
Gene Ontology Biological Process
- blood coagulation [TAS]
- carbohydrate metabolic process [TAS]
- cartilage development [IEP]
- cell-matrix adhesion [NAS]
- cellular response to fibroblast growth factor stimulus [IDA]
- cytokine-mediated signaling pathway [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- glycosaminoglycan metabolic process [TAS]
- hyaluronan catabolic process [IDA, TAS]
- hyaluronan metabolic process [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte migration [TAS]
- monocyte aggregation [IMP]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of heterotypic cell-cell adhesion [IMP]
- positive regulation of monocyte aggregation [IMP]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- single organismal cell-cell adhesion [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TGFBR1
Gene Ontology Biological Process
- activation of MAPKK activity [IDA]
- anterior/posterior pattern specification [ISS]
- artery morphogenesis [ISS]
- cell cycle arrest [TAS]
- cell motility [IMP]
- cellular response to transforming growth factor beta stimulus [IDA]
- collagen fibril organization [ISS]
- embryonic cranial skeleton morphogenesis [ISS]
- epithelial to mesenchymal transition [IDA]
- extracellular structure organization [TAS]
- germ cell migration [ISS]
- heart development [ISS]
- in utero embryonic development [ISS]
- kidney development [ISS]
- mesenchymal cell differentiation [TAS]
- negative regulation of chondrocyte differentiation [ISS]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- neuron fate commitment [ISS]
- palate development [ISS]
- parathyroid gland development [ISS]
- pathway-restricted SMAD protein phosphorylation [IDA]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- pharyngeal system development [ISS]
- positive regulation of SMAD protein import into nucleus [IDA]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of cellular component movement [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- regulation of protein ubiquitination [IDA]
- regulation of transcription, DNA-templated [IDA, IMP]
- response to cholesterol [IDA]
- signal transduction [IDA]
- skeletal system development [ISS]
- skeletal system morphogenesis [ISS]
- thymus development [ISS]
- transforming growth factor beta receptor signaling pathway [IC, IDA, IMP, TAS]
- wound healing [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- I-SMAD binding [IPI]
- SMAD binding [IDA, IPI]
- growth factor binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IDA, IMP, IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- type II transforming growth factor beta receptor binding [IDA, IPI]
- ATP binding [IDA]
- I-SMAD binding [IPI]
- SMAD binding [IDA, IPI]
- growth factor binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IDA, IMP, IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- type II transforming growth factor beta receptor binding [IDA, IPI]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells.
In this study we have examined the interaction between CD44 (a hyaluronan (HA) receptor) and the transforming growth factor beta (TGF-beta) receptors (a family of serine/threonine kinase membrane receptors) in human metastatic breast tumor cells (MDA-MB-231 cell line). Immunological data indicate that both CD44 and TGF-beta receptors are expressed in MDA-MB-231 cells and that CD44 is physically linked to the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CD44 TGFBR1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| TGFBR1 CD44 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID