PLXNA1
Gene Ontology Biological Process
Gene Ontology Molecular Function
NRP2
Gene Ontology Biological Process
- axon extension involved in axon guidance [IMP]
- axon guidance [IMP]
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus [IMP]
- heart development [IGI]
- negative chemotaxis [IGI, IMP]
- nerve development [IMP]
- neural crest cell migration [IMP]
- neuron migration [IMP]
- semaphorin-plexin signaling pathway [IDA]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [IMP]
- sympathetic ganglion development [IMP]
- sympathetic neuron projection extension [IMP]
- sympathetic neuron projection guidance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [IDA]
- plasma membrane [IC]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.
Class 1 and 3 semaphorins repulse axons but bind to different cell surface proteins. We find that the two known semaphorin-binding proteins, plexin 1 (Plex 1) and neuropilin-1 (NP-1), form a stable complex. Plex 1 alone does not bind semaphorin-3A (Sema3A), but the NP-1/Plex 1 complex has a higher affinity for Sema3A than does NP-1 alone. While Sema3A binding to ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID