BAIT
FLNA
ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD, XX-FW83128A1.1
filamin A, alpha
GO Process (19)
GO Function (12)
GO Component (10)
Gene Ontology Biological Process
- actin crosslink formation [IDA]
- actin cytoskeleton reorganization [IDA]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IMP]
- blood coagulation [TAS]
- cell junction assembly [TAS]
- cilium assembly [IMP]
- cytoplasmic sequestering of protein [IMP]
- establishment of protein localization [IDA]
- negative regulation of protein catabolic process [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- platelet activation [TAS]
- platelet aggregation [IMP]
- platelet degranulation [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of transcription factor import into nucleus [IMP]
- protein localization to cell surface [IDA]
- protein stabilization [IMP]
- receptor clustering [IDA]
- spindle assembly involved in mitosis [IDA]
Gene Ontology Molecular Function- Fc-gamma receptor I complex binding [IDA]
- Rac GTPase binding [IDA]
- Ral GTPase binding [IDA]
- Rho GTPase binding [IDA]
- actin filament binding [IDA]
- glycoprotein binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- signal transducer activity [IMP]
- small GTPase binding [IDA]
- transcription factor binding [IPI]
- Fc-gamma receptor I complex binding [IDA]
- Rac GTPase binding [IDA]
- Ral GTPase binding [IDA]
- Rho GTPase binding [IDA]
- actin filament binding [IDA]
- glycoprotein binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- signal transducer activity [IMP]
- small GTPase binding [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
F3
CD142, TF, TFA
coagulation factor III (thromboplastin, tissue factor)
GO Process (12)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- activation of blood coagulation via clotting cascade [IC]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- activation of plasma proteins involved in acute inflammatory response [IDA]
- blood coagulation [TAS]
- blood coagulation, extrinsic pathway [TAS]
- cytokine-mediated signaling pathway [IBA]
- positive regulation of angiogenesis [IDA]
- positive regulation of cell migration [TAS]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- positive regulation of positive chemotaxis [IC]
- positive regulation of protein kinase B signaling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280.
Tissue factor (TF), the protease receptor initiating the coagulation system, functions in vascular development, angiogenesis, and tumor cell metastasis by poorly defined molecular mechanisms. We demonstrate that immobilized ligands for TF specifically support cell adhesion, migration, spreading, and intracellular signaling, which are not inhibited by RGD peptides. Two-hybrid screening identified actin-binding protein 280 (ABP-280) as ligand for the TF cytoplasmic ... [more]
J. Cell Biol. Mar. 09, 1998; 140(5);1241-53 [Pubmed: 9490735]
Throughput
- Low Throughput
Curated By
- BioGRID