GIPC1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [NAS]
- endothelial cell migration [ISS]
- glutamate secretion [ISS]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- positive regulation of cytokinesis [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISS]
- protein targeting [ISS]
- regulation of protein stability [ISS]
- regulation of synaptic plasticity [ISS]
- synaptic transmission [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ITGA6
Gene Ontology Biological Process
- amelogenesis [IMP]
- blood coagulation [TAS]
- cell junction assembly [TAS]
- cell-substrate adhesion [IMP]
- cell-substrate junction assembly [TAS]
- digestive tract development [IMP]
- ectodermal cell differentiation [IEP]
- extracellular matrix organization [TAS]
- hemidesmosome assembly [TAS]
- leukocyte migration [TAS]
- nail development [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of apoptotic process [IGI]
- positive regulation of phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- renal system development [IMP]
- skin development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B.
We used published peptide library data to identify PDZ recognition sequences in integrin alpha subunit cytoplasmic domains and found that the alpha(6)A and alpha(5) subunits contain a type I PDZ binding site (TSDA*) (asterisk indicates the stop codon). The alpha(6)A cytoplasmic domain was used for screening a two-hybrid library to find interacting proteins. The bulk of the captured cDNAs (60%) ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ITGA6 GIPC1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| ITGA6 GIPC1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID