SH3GL2
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- central nervous system development [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- membrane organization [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- post-Golgi vesicle-mediated transport [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ADAM9
Gene Ontology Biological Process
- PMA-inducible membrane protein ectodomain proteolysis [IDA, TAS]
- activation of MAPKK activity [IDA]
- cell adhesion [IMP]
- cell adhesion mediated by integrin [IMP]
- cell-cell adhesion mediated by integrin [IEP]
- cell-matrix adhesion [IMP]
- cellular response to lipopolysaccharide [IMP]
- collagen catabolic process [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- integrin-mediated signaling pathway [IC]
- keratinocyte differentiation [IEP]
- membrane protein ectodomain proteolysis [IDA, IMP]
- monocyte activation [IMP]
- positive regulation of cell adhesion mediated by integrin [IMP]
- positive regulation of keratinocyte migration [IMP]
- positive regulation of macrophage fusion [IMP]
- positive regulation of membrane protein ectodomain proteolysis [ISS]
- positive regulation of protein secretion [IDA]
- response to calcium ion [IMP]
- response to glucocorticoid [ISS]
- response to hydrogen peroxide [IMP]
- response to manganese ion [IMP]
- response to tumor necrosis factor [IDA]
- transforming growth factor beta receptor signaling pathway [IMP, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.
Metalloprotease disintegrins (a disintegrin and metalloprotease (ADAM) and metalloprotease, disintegrin, cysteine-rich proteins (MDC)) are a family of membrane-anchored glycoproteins that function in diverse biological processes, including fertilization, neurogenesis, myogenesis, and ectodomain processing of cytokines and other proteins. The cytoplasmic domains of ADAMs often include putative signaling motifs, such as proline-rich SH3 ligand domains, suggesting that interactions with cytoplasmic proteins may ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ADAM9 SH3GL2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
ADAM9 SH3GL2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID