RPH3A
Gene Ontology Molecular Function- calcium ion binding [ISS]
- calcium-dependent phospholipid binding [ISS]
- inositol 1,4,5 trisphosphate binding [ISS]
- phosphate ion binding [ISS]
- phosphatidylinositol phosphate binding [TAS]
- phosphatidylinositol-4,5-bisphosphate binding [ISS]
- protein binding [IPI]
- protein complex binding [ISS]
- selenium binding [ISS]
- zinc ion binding [ISS]
- calcium ion binding [ISS]
- calcium-dependent phospholipid binding [ISS]
- inositol 1,4,5 trisphosphate binding [ISS]
- phosphate ion binding [ISS]
- phosphatidylinositol phosphate binding [TAS]
- phosphatidylinositol-4,5-bisphosphate binding [ISS]
- protein binding [IPI]
- protein complex binding [ISS]
- selenium binding [ISS]
- zinc ion binding [ISS]
Gene Ontology Cellular Component
RAB3A
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- Rab protein signal transduction [IBA]
- constitutive secretory pathway [TAS]
- glutamate secretion [TAS]
- intracellular protein transport [IBA]
- neurotransmitter secretion [TAS]
- positive regulation of exocytosis [TAS]
- positive regulation of regulated secretory pathway [IMP]
- protein localization to plasma membrane [IBA]
- protein secretion [IBA]
- regulation of short-term neuronal synaptic plasticity [ISS]
- regulation of synaptic vesicle fusion to presynaptic membrane [ISS]
- synaptic transmission [TAS]
- synaptic vesicle exocytosis [ISS]
- synaptic vesicle recycling [ISS]
- vesicle docking involved in exocytosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [ISS]
- clathrin-sculpted acetylcholine transport vesicle membrane [TAS]
- clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [TAS]
- clathrin-sculpted glutamate transport vesicle membrane [TAS]
- clathrin-sculpted monoamine transport vesicle membrane [TAS]
- endosome [IBA]
- plasma membrane [TAS]
- secretory granule membrane [IBA]
- synaptic vesicle [ISS]
- terminal bouton [ISS]
- vesicle [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells.
Rab3A and Rab3B are highly homologous monomeric GTPases that are putative regulators of exocytosis in those tissues in which they are expressed. We have characterized and directly compared the targeting and functional properties of these isoforms in PC12 neuroendocrine cells. Rab3A and Rab3B both targeted to norepinephrine (NE)-containing large dense core vesicles (LDCVs) when stably expressed in PC12 cells, as ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAB3A RPH3A | Co-crystal Structure Co-crystal Structure Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex. | Low | - | BioGRID | - |
Curated By
- BioGRID