BAIT
MCL1
BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT
myeloid cell leukemia 1
GO Process (11)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- cell fate determination [NAS]
- cellular homeostasis [NAS]
- extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA]
- negative regulation of anoikis [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- negative regulation of intrinsic apoptotic signaling pathway [IBA]
- positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IGI]
- protein transmembrane transport [TAS]
- regulation of response to DNA damage stimulus [IMP]
- response to cytokine [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
BOK
BCL2L9, BOKL
BCL2-related ovarian killer
GO Process (7)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic process [IDA]
- cell proliferation [IEP]
- extrinsic apoptotic signaling pathway in absence of ligand [IBA]
- intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA]
- positive regulation of execution phase of apoptosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members.
In the intracellular death program, hetero- and homodimerization of different anti- and pro-apoptotic Bcl-2-related proteins are critical in the determination of cell fate. From a rat ovarian fusion cDNA library, we isolated a new pro-apoptotic Bcl-2 gene, Bcl-2-related ovarian killer (Bok). Bok had conserved Bcl-2 homology (BH) domains 1, 2, and 3 and a C-terminal transmembrane region present in other ... [more]
Proc. Natl. Acad. Sci. U.S.A. Nov. 11, 1997; 94(23);12401-6 [Pubmed: 9356461]
Throughput
- Low Throughput
Curated By
- BioGRID