BAIT

SH3GLB1

Bif-1, PPP1R70, dJ612B15.2, CGI-61
SH3-domain GRB2-like endophilin B1
Autophagy Project
GO Process (2)
GO Function (3)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

SH3KBP1

CD2BP3, CIN85, GIG10, HSB-1, HSB1, MIG18, RP11-345L8.1
SH3-domain kinase binding protein 1
UPS Project
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.

Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S

Ligand-dependent downregulation of tyrosine kinase receptors is a critical step for modulating their activity. Upon ligand binding, hepatocyte growth factor (HGF) receptor (Met) is polyubiquitinated and degraded; however, the mechanisms underlying HGF receptor endocytosis are not yet known. Here we demonstrate that a complex involving endophilins, CIN85 and Cbl controls this process. Endophilins are regulatory components of clathrin-coated vesicle formation. ... [more]

Nature Mar. 14, 2002; 416(6877);187-90 [Pubmed: 11894096]

Throughput

  • Low Throughput

Curated By

  • BioGRID