BAIT

RNF216

CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN
ring finger protein 216
Homo sapiens
PREY

TLR9

CD289, UNQ5798/PRO19605
toll-like receptor 9
GO Process (33)
GO Function (2)
GO Component (13)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.

Chuang TH, Ulevitch RJ

Activation of Toll-like receptors (TLRs) results in a proinflammatory response needed to combat infection. Thus, limiting TLR signaling is essential for preventing a protective response from causing injury to the host. Here we describe how a RING finger protein, Triad3A, acts as an E3 ubiquitin-protein ligase and enhances ubiquitination and proteolytic degradation of some TLRs. Triad3A overexpression promoted substantial degradation ... [more]

Nat. Immunol. May. 01, 2004; 5(5);495-502 [Pubmed: 15107846]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
TLR9 RNF216
Two-hybrid
Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Low-BioGRID
-

Curated By

  • BioGRID