BAIT
HTRA2
OMI, PARK13, PRSS25
HtrA serine peptidase 2
GO Process (19)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- cellular protein catabolic process [IDA]
- cellular response to growth factor stimulus [IMP]
- cellular response to heat [IDA]
- cellular response to interferon-beta [IDA]
- cellular response to oxidative stress [NAS]
- cellular response to retinoic acid [IDA]
- execution phase of apoptosis [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of cell cycle [TAS]
- negative regulation of neuron death [TAS]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [NAS]
- positive regulation of apoptotic process [IMP, TAS]
- positive regulation of cell death [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [IMP]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- protein autoprocessing [TAS]
- proteolysis [IMP, TAS]
- regulation of mitochondrion degradation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
C1QBP
GC1QBP, HABP1, SF2p32, gC1Q-R, gC1qR, p32
complement component 1, q subcomponent binding protein
GO Process (21)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- immune response [TAS]
- mature ribosome assembly [IMP]
- negative regulation of MDA-5 signaling pathway [IDA]
- negative regulation of RIG-I signaling pathway [IDA]
- negative regulation of defense response to virus [IMP]
- negative regulation of interferon-gamma production [IDA]
- negative regulation of interleukin-12 production [IDA]
- negative regulation of mRNA splicing, via spliceosome [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell adhesion [IMP]
- positive regulation of dendritic cell chemotaxis [IMP]
- positive regulation of mitochondrial translation [ISS]
- positive regulation of neutrophil chemotaxis [IDA]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IMP]
- positive regulation of trophoblast cell migration [IMP]
- regulation of complement activation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.
A number of unique proteases localize to specific sub-compartments of the mitochondria, but the functions of these enzymes are poorly defined. Here, in vivo proximity-dependent biotinylation (BioID) is used to map the interactomes of seven proteases localized to the mitochondrial intermembrane space (IMS). In total, 802 high confidence proximity interactions with 342 unique proteins are identified. While all seven proteases ... [more]
Proteomics Dec. 01, 2018; 19(24);e1900139 [Pubmed: 31617661]
Throughput
- High Throughput
Curated By
- BioGRID