BAIT
IMMP1L
IMP1, IMP1-LIKE
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
GO Process (0)
GO Function (0)
GO Component (1)
Gene Ontology Cellular Component
Homo sapiens
PREY
TBK1
NAK, T2K
TANK-binding kinase 1
GO Process (17)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- inflammatory response [TAS]
- innate immune response [TAS]
- negative regulation of type I interferon production [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of interferon-alpha production [IDA]
- positive regulation of interferon-beta production [IDA]
- positive regulation of peptidyl-serine phosphorylation [NAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of type I interferon production [TAS]
- response to virus [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- type I interferon production [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.
A number of unique proteases localize to specific sub-compartments of the mitochondria, but the functions of these enzymes are poorly defined. Here, in vivo proximity-dependent biotinylation (BioID) is used to map the interactomes of seven proteases localized to the mitochondrial intermembrane space (IMS). In total, 802 high confidence proximity interactions with 342 unique proteins are identified. While all seven proteases ... [more]
Proteomics Dec. 01, 2018; 19(24);e1900139 [Pubmed: 31617661]
Throughput
- High Throughput
Curated By
- BioGRID