CXCR2
Gene Ontology Biological Process
- cell surface receptor signaling pathway [IDA]
- cellular defense response [IDA]
- chemokine-mediated signaling pathway [IDA]
- chemotaxis [IDA]
- dendritic cell chemotaxis [TAS]
- inflammatory response [TAS]
- interleukin-8-mediated signaling pathway [IDA]
- neutrophil activation [IDA]
- neutrophil chemotaxis [IDA]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- positive regulation of cell proliferation [IDA]
- receptor internalization [IDA]
- signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CXCL8
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- angiogenesis [TAS]
- calcium-mediated signaling [TAS]
- cell cycle arrest [IDA]
- cellular component movement [TAS]
- cellular protein metabolic process [TAS]
- cellular response to fibroblast growth factor stimulus [IEP]
- cellular response to interleukin-1 [IEP]
- cellular response to lipopolysaccharide [IDA]
- cellular response to tumor necrosis factor [IEP]
- chemokine-mediated signaling pathway [IBA]
- chemotaxis [TAS]
- embryonic digestive tract development [IEP]
- endoplasmic reticulum unfolded protein response [TAS]
- immune response [IBA]
- induction of positive chemotaxis [IGI]
- inflammatory response [TAS]
- intracellular signal transduction [IDA]
- negative regulation of G-protein coupled receptor protein signaling pathway [IDA]
- negative regulation of cell proliferation [TAS]
- neutrophil activation [TAS]
- neutrophil chemotaxis [IGI]
- positive regulation of neutrophil chemotaxis [TAS]
- receptor internalization [IDA]
- regulation of cell adhesion [IDA]
- regulation of single stranded viral RNA replication via double stranded DNA intermediate [IDA]
- response to endoplasmic reticulum stress [IDA]
- response to molecule of bacterial origin [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Molecular modeling of interleukin-8 receptor beta and analysis of the receptor-ligand interaction.
A structural model of interleukin-8 receptor type beta (IL-8R-beta) was constructed based on the structure of bacteriorhodopsin. High temperature molecular dynamics simulations were performed to search the possible conformations of loop regions in IL-8R-beta which recognize the ligand. The crystal structure of interleukin 8 (IL-8) was used as a geometric constraint of the extracellular loop regions of IL-8R-beta in the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID