Publication

Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import.

Koehler M, Speck C, Christiansen M, Bischoff FR, Prehn S, Haller H, Goerlich D, Hartmann E

Importin alpha plays a pivotal role in the classical nuclear protein import pathway. Importin alpha shuttles between nucleus and cytoplasm, binds nuclear localization signal-bearing proteins, and functions as an adapter to access the importin beta-dependent import pathway. In contrast to what is found for importin beta, several isoforms of importin alpha, which can be grouped into three subfamilies, exist in ... [more]

Throughput

• Low Throughput

Curated By

• BioGRID