TEK
Gene Ontology Biological Process
- Tie signaling pathway [ISO, TAS]
- angiogenesis [IMP, TAS]
- cell-matrix adhesion [IMP]
- endothelial cell proliferation [IMP]
- heart development [IMP]
- heart trabecula formation [IMP]
- hemopoiesis [IMP]
- intracellular signal transduction [ISO]
- negative regulation of angiogenesis [ISO]
- negative regulation of apoptotic process [IGI]
- negative regulation of endothelial cell apoptotic process [IMP]
- patterning of blood vessels [TAS]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of actin cytoskeleton reorganization [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell adhesion [IMP]
- positive regulation of cytokine secretion involved in immune response [IDA]
- positive regulation of endothelial cell migration [ISO, TAS]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of intracellular signal transduction [ISO]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein import into nucleus [IDA]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein phosphorylation [IDA, ISO]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [TAS]
- protein autophosphorylation [ISO]
- protein oligomerization [ISO]
- regulation of NIK/NF-kappaB signaling [IGI]
- regulation of angiogenesis [IMP]
- regulation of cell migration [IDA, IMP]
- regulation of endothelial cell proliferation [TAS]
- regulation of establishment or maintenance of cell polarity [ISO]
- response to estrogen [ISO]
- response to retinoic acid [IDA]
- single organismal cell-cell adhesion [IMP]
- sprouting angiogenesis [ISO]
- substrate adhesion-dependent cell spreading [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin filament [ISO]
- apical plasma membrane [ISO]
- basal plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- cell surface [ISO]
- cell-cell junction [ISO]
- integral component of membrane [ISM]
- integral component of plasma membrane [ISO]
- membrane raft [ISO]
- microvillus [ISO]
- perinuclear region of cytoplasm [IDA]
- stress fiber [ISO]
GRB14
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.
The Tek/Tie2 receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development. To study the signal transduction pathways that are mediated by this receptor, we have used the yeast two-hybrid system to identify signaling molecules that associate with the phosphorylated Tek receptor. Using this approach, we demonstrate that five molecules, Grb2, Grb7, Grb14, Shp2, and the p85 subunit ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TEK GRB14 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID