BAIT
TEK
AA517024, Cd202b, Hyk, STK1, Tie-2, Tie2, RP23-345A23.1
endothelial-specific receptor tyrosine kinase
GO Process (42)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- Tie signaling pathway [ISO, TAS]
- angiogenesis [IMP, TAS]
- cell-matrix adhesion [IMP]
- endothelial cell proliferation [IMP]
- heart development [IMP]
- heart trabecula formation [IMP]
- hemopoiesis [IMP]
- intracellular signal transduction [ISO]
- negative regulation of angiogenesis [ISO]
- negative regulation of apoptotic process [IGI]
- negative regulation of endothelial cell apoptotic process [IMP]
- patterning of blood vessels [TAS]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of actin cytoskeleton reorganization [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell adhesion [IMP]
- positive regulation of cytokine secretion involved in immune response [IDA]
- positive regulation of endothelial cell migration [ISO, TAS]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of intracellular signal transduction [ISO]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein import into nucleus [IDA]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein phosphorylation [IDA, ISO]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [TAS]
- protein autophosphorylation [ISO]
- protein oligomerization [ISO]
- regulation of NIK/NF-kappaB signaling [IGI]
- regulation of angiogenesis [IMP]
- regulation of cell migration [IDA, IMP]
- regulation of endothelial cell proliferation [TAS]
- regulation of establishment or maintenance of cell polarity [ISO]
- response to estrogen [ISO]
- response to retinoic acid [IDA]
- single organismal cell-cell adhesion [IMP]
- sprouting angiogenesis [ISO]
- substrate adhesion-dependent cell spreading [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin filament [ISO]
- apical plasma membrane [ISO]
- basal plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- cell surface [ISO]
- cell-cell junction [ISO]
- integral component of membrane [ISM]
- integral component of plasma membrane [ISO]
- membrane raft [ISO]
- microvillus [ISO]
- perinuclear region of cytoplasm [IDA]
- stress fiber [ISO]
Mus musculus
PREY
PTPN11
2700084A17Rik, AW536184, PTP1D, PTP2C, SAP-2, SH-PTP2, SH-PTP3, SHP-2, Shp2, Syp
protein tyrosine phosphatase, non-receptor type 11
GO Process (41)
GO Function (12)
GO Component (8)
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- ERBB signaling pathway [ISO]
- abortive mitotic cell cycle [IMP]
- activation of MAPK activity [IMP]
- atrioventricular canal development [ISO]
- axonogenesis [IMP]
- brain development [ISO]
- dephosphorylation [IMP]
- ephrin receptor signaling pathway [ISO]
- epidermal growth factor receptor signaling pathway [IGI]
- face morphogenesis [ISO]
- genitalia development [ISO]
- glucose homeostasis [IMP]
- heart development [ISO]
- hormone metabolic process [IMP]
- hormone-mediated signaling pathway [IDA]
- inner ear development [ISO]
- integrin-mediated signaling pathway [IMP]
- lipid metabolic process [IMP]
- megakaryocyte development [IMP]
- multicellular organismal reproductive process [IMP]
- negative regulation of cell adhesion mediated by integrin [IMP]
- negative regulation of cortisol secretion [IMP]
- negative regulation of growth hormone secretion [IMP]
- negative regulation of hormone secretion [IMP]
- negative regulation of insulin secretion [IMP]
- neurotrophin TRK receptor signaling pathway [IMP]
- organ growth [IMP]
- peptidyl-tyrosine dephosphorylation [IDA, ISO]
- platelet formation [IGI]
- platelet-derived growth factor receptor signaling pathway [IGI]
- positive regulation of ERK1 and ERK2 cascade [IGI]
- positive regulation of glucose import in response to insulin stimulus [ISO]
- positive regulation of hormone secretion [IMP]
- positive regulation of mitotic cell cycle [IGI]
- positive regulation of signal transduction [IMP, ISO]
- protein dephosphorylation [ISO]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of protein export from nucleus [IMP]
- triglyceride metabolic process [IMP]
Gene Ontology Molecular Function- D1 dopamine receptor binding [ISO]
- SH3/SH2 adaptor activity [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- non-membrane spanning protein tyrosine phosphatase activity [ISO]
- peptide hormone receptor binding [IPI]
- phospholipase binding [ISO]
- phosphoprotein phosphatase activity [IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein tyrosine phosphatase activity [IDA, ISO]
- receptor tyrosine kinase binding [IPI]
- D1 dopamine receptor binding [ISO]
- SH3/SH2 adaptor activity [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- non-membrane spanning protein tyrosine phosphatase activity [ISO]
- peptide hormone receptor binding [IPI]
- phospholipase binding [ISO]
- phosphoprotein phosphatase activity [IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein tyrosine phosphatase activity [IDA, ISO]
- receptor tyrosine kinase binding [IPI]
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.
The Tek/Tie2 receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development. To study the signal transduction pathways that are mediated by this receptor, we have used the yeast two-hybrid system to identify signaling molecules that associate with the phosphorylated Tek receptor. Using this approach, we demonstrate that five molecules, Grb2, Grb7, Grb14, Shp2, and the p85 subunit ... [more]
J. Biol. Chem. Oct. 22, 1999; 274(43);30896-905 [Pubmed: 10521483]
Throughput
- Low Throughput
Curated By
- BioGRID