BAIT
TEK
AA517024, Cd202b, Hyk, STK1, Tie-2, Tie2, RP23-345A23.1
endothelial-specific receptor tyrosine kinase
GO Process (42)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- Tie signaling pathway [ISO, TAS]
- angiogenesis [IMP, TAS]
- cell-matrix adhesion [IMP]
- endothelial cell proliferation [IMP]
- heart development [IMP]
- heart trabecula formation [IMP]
- hemopoiesis [IMP]
- intracellular signal transduction [ISO]
- negative regulation of angiogenesis [ISO]
- negative regulation of apoptotic process [IGI]
- negative regulation of endothelial cell apoptotic process [IMP]
- patterning of blood vessels [TAS]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of actin cytoskeleton reorganization [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell adhesion [IMP]
- positive regulation of cytokine secretion involved in immune response [IDA]
- positive regulation of endothelial cell migration [ISO, TAS]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of intracellular signal transduction [ISO]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein import into nucleus [IDA]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein phosphorylation [IDA, ISO]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [TAS]
- protein autophosphorylation [ISO]
- protein oligomerization [ISO]
- regulation of NIK/NF-kappaB signaling [IGI]
- regulation of angiogenesis [IMP]
- regulation of cell migration [IDA, IMP]
- regulation of endothelial cell proliferation [TAS]
- regulation of establishment or maintenance of cell polarity [ISO]
- response to estrogen [ISO]
- response to retinoic acid [IDA]
- single organismal cell-cell adhesion [IMP]
- sprouting angiogenesis [ISO]
- substrate adhesion-dependent cell spreading [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin filament [ISO]
- apical plasma membrane [ISO]
- basal plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- cell surface [ISO]
- cell-cell junction [ISO]
- integral component of membrane [ISM]
- integral component of plasma membrane [ISO]
- membrane raft [ISO]
- microvillus [ISO]
- perinuclear region of cytoplasm [IDA]
- stress fiber [ISO]
Mus musculus
PREY
PTPN11
2700084A17Rik, AW536184, PTP1D, PTP2C, SAP-2, SH-PTP2, SH-PTP3, SHP-2, Shp2, Syp
protein tyrosine phosphatase, non-receptor type 11
GO Process (41)
GO Function (12)
GO Component (8)
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- ERBB signaling pathway [ISO]
- abortive mitotic cell cycle [IMP]
- activation of MAPK activity [IMP]
- atrioventricular canal development [ISO]
- axonogenesis [IMP]
- brain development [ISO]
- dephosphorylation [IMP]
- ephrin receptor signaling pathway [ISO]
- epidermal growth factor receptor signaling pathway [IGI]
- face morphogenesis [ISO]
- genitalia development [ISO]
- glucose homeostasis [IMP]
- heart development [ISO]
- hormone metabolic process [IMP]
- hormone-mediated signaling pathway [IDA]
- inner ear development [ISO]
- integrin-mediated signaling pathway [IMP]
- lipid metabolic process [IMP]
- megakaryocyte development [IMP]
- multicellular organismal reproductive process [IMP]
- negative regulation of cell adhesion mediated by integrin [IMP]
- negative regulation of cortisol secretion [IMP]
- negative regulation of growth hormone secretion [IMP]
- negative regulation of hormone secretion [IMP]
- negative regulation of insulin secretion [IMP]
- neurotrophin TRK receptor signaling pathway [IMP]
- organ growth [IMP]
- peptidyl-tyrosine dephosphorylation [IDA, ISO]
- platelet formation [IGI]
- platelet-derived growth factor receptor signaling pathway [IGI]
- positive regulation of ERK1 and ERK2 cascade [IGI]
- positive regulation of glucose import in response to insulin stimulus [ISO]
- positive regulation of hormone secretion [IMP]
- positive regulation of mitotic cell cycle [IGI]
- positive regulation of signal transduction [IMP, ISO]
- protein dephosphorylation [ISO]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of protein export from nucleus [IMP]
- triglyceride metabolic process [IMP]
Gene Ontology Molecular Function- D1 dopamine receptor binding [ISO]
- SH3/SH2 adaptor activity [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- non-membrane spanning protein tyrosine phosphatase activity [ISO]
- peptide hormone receptor binding [IPI]
- phospholipase binding [ISO]
- phosphoprotein phosphatase activity [IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein tyrosine phosphatase activity [IDA, ISO]
- receptor tyrosine kinase binding [IPI]
- D1 dopamine receptor binding [ISO]
- SH3/SH2 adaptor activity [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- non-membrane spanning protein tyrosine phosphatase activity [ISO]
- peptide hormone receptor binding [IPI]
- phospholipase binding [ISO]
- phosphoprotein phosphatase activity [IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein tyrosine phosphatase activity [IDA, ISO]
- receptor tyrosine kinase binding [IPI]
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.
The Tek/Tie2 receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development. To study the signal transduction pathways that are mediated by this receptor, we have used the yeast two-hybrid system to identify signaling molecules that associate with the phosphorylated Tek receptor. Using this approach, we demonstrate that five molecules, Grb2, Grb7, Grb14, Shp2, and the p85 subunit ... [more]
J. Biol. Chem. Oct. 22, 1999; 274(43);30896-905 [Pubmed: 10521483]
Throughput
- Low Throughput
Curated By
- BioGRID